Acetate-free hemodialysis: a feasibility study on a technical alternative to bicarbonate dialysis

Blood Purification
E Duranti

Abstract

This study aimed at evaluating the feasibility of an acetate-free hemodialysis (AFHD) technique, comparing it with acetate-free biofiltration (AFB) and bicarbonate dialysis (BD). The assessment of the parameters concerned: electrolyte kinetics (Na+, K+), acid-base balance (HCO3-, pH), dialysis efficiency (Kt/V), serum beta2-microglobulin reduction ratio, nutritional status (normalized protein catabolic rate, serum albumin and total proteins, body mass index), hemopoietic status (hemoglobin, hematocrit), and some clinical parameters (systolic and diastolic blood pressures, heart rate, percent blood volume reduction measured by Hemoscan). Nine patients participated in this study which was conducted using a Latin square randomized experimental design. The results of the last week of each month of the study (1 month for each technique) were analyzed by means of Anova for repeated measures. The different treatments were comparable with regard to the main dialysis parameters such as blood flow (320 ml/min) and weight loss rate (0.6 +/- 0.1 kg/h), while dialysis length and dialysate conductivities were different, depending on the dialysis technique. Electrolyte kinetics and acid-base balance were similar during the three periods. The ...Continue Reading

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Citations

Dec 7, 2010·Néphrologie & thérapeutique·Thierry PetitclercJalel Hmida
May 21, 2015·The Cochrane Database of Systematic Reviews·Ionut NistorGiovanni F M Strippoli

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