PMID: 6762188Nov 1, 1982Paper

Acetate metabolism during hemodialysis

Artificial Organs
M W Weiner

Abstract

We infused acetate into normal human subjects and performed kinetic analysis of the plasma and urine values obtained before, during, and after the infusion. The data were best fitted by a first-order elimination process with a mean metabolic clearance rate of 2.3 L/min. Gotch and Sargent had previously suggested that during dialysis, acetate metabolism was zero order. We performed kinetic modeling of acetate concentrations during dialysis. The data were best fitted to a Michaelis-Menton model (i.e., first-order metabolism at low concentrations and saturated at high concentrations). The mean Km for acetate in the dialysis patients was 8.5 mM and the mean Vmax was 18 mmol/min. Patients with a Vmax less than 7 mmol/min usually had a fall in plasma bicarbonate during dialysis while patients with a Vmax greater than 14 mmol/min usually had a rise in bicarbonate during dialysis. It is concluded that during high-surface-area dialysis, the capacity for acetate metabolism will affect acid-base homeostasis. Kinetic modeling will be useful to define acetate-intolerant patients and may be used to predict patients who will benefit from bicarbonate hemodialysis.

References

Mar 1, 1978·Annals of Internal Medicine·U GraefeB H Scribner
Jun 1, 1979·Kidney International·K J Wingert, M W Weiner
Nov 1, 1979·Diabetes·D UrionM W Weiner
Sep 15, 1977·The Biochemical Journal·B M Buckley, D H Williamson
Oct 1, 1978·The American Journal of Clinical Nutrition·R L WathenC M Comty
Jan 1, 1978·Journal of Dialysis·Y AizawaY Hirasawa
Jul 1, 1977·Antimicrobial Agents and Chemotherapy·H R SullivanW M Miller
May 1, 1977·Kidney International·N TolchinE J Lewis
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·E SavdieJ H Stewart
Feb 1, 1976·Chest·J M LetteriJ W Ledwith
Sep 1, 1973·Analytical Biochemistry·S C Kuo, E S Younathan
Aug 1, 1974·The Biochemical Journal·S E KnowlesF J Ballard
Aug 1, 1972·The American Journal of Clinical Nutrition·F J Ballard
Mar 28, 1974·The New England Journal of Medicine·A LindnerB H Scribner
Nov 1, 1971·JAMA : the Journal of the American Medical Association·B T BurtonF A Bryan
Jan 1, 1981·American Journal of Nephrology·H F BorgesC M Kjellstrand
Feb 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R W PattersonS F Sullivan
Nov 1, 1982·Artificial Organs·P R Keshaviah
Aug 1, 1961·The Biochemical Journal·F LUNDQUISTH RASMUSSEN
Oct 29, 1960·Nature·I G JARRETT, O H FILSELL
Jan 1, 1962·The British Journal of Nutrition·K L BLAXTER
Feb 10, 1962·Nature·F LUNDQUIST

Citations

Jul 30, 1983·British Medical Journal·M A Mansell, A J Wing
Jun 1, 1984·Biomedizinische Technik. Biomedical Engineering·H HamplM Kessel
Jul 1, 1987·Kidney International·J T Daugirdas, Z M Nawab
Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·W E Harmon
Apr 15, 2019·Néphrologie & thérapeutique·Myriam DaoLucile Mercadal

Related Concepts

Acetic Acids
Carbonic Acid Ions
Hemodialysis
Lipids
NADH
Vinegar

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.