PMID: 6762188Nov 1, 1982Paper

Acetate metabolism during hemodialysis

Artificial Organs
M W Weiner


We infused acetate into normal human subjects and performed kinetic analysis of the plasma and urine values obtained before, during, and after the infusion. The data were best fitted by a first-order elimination process with a mean metabolic clearance rate of 2.3 L/min. Gotch and Sargent had previously suggested that during dialysis, acetate metabolism was zero order. We performed kinetic modeling of acetate concentrations during dialysis. The data were best fitted to a Michaelis-Menton model (i.e., first-order metabolism at low concentrations and saturated at high concentrations). The mean Km for acetate in the dialysis patients was 8.5 mM and the mean Vmax was 18 mmol/min. Patients with a Vmax less than 7 mmol/min usually had a fall in plasma bicarbonate during dialysis while patients with a Vmax greater than 14 mmol/min usually had a rise in bicarbonate during dialysis. It is concluded that during high-surface-area dialysis, the capacity for acetate metabolism will affect acid-base homeostasis. Kinetic modeling will be useful to define acetate-intolerant patients and may be used to predict patients who will benefit from bicarbonate hemodialysis.


Mar 1, 1978·Annals of Internal Medicine·U GraefeB H Scribner
Jun 1, 1979·Kidney International·K J Wingert, M W Weiner
Nov 1, 1979·Diabetes·D UrionM W Weiner
Sep 15, 1977·The Biochemical Journal·B M Buckley, D H Williamson
Oct 1, 1978·The American Journal of Clinical Nutrition·R L WathenC M Comty
Jan 1, 1978·Journal of Dialysis·Y AizawaY Hirasawa
Jul 1, 1977·Antimicrobial Agents and Chemotherapy·H R SullivanW M Miller
May 1, 1977·Kidney International·N TolchinE J Lewis
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·E SavdieJ H Stewart
Feb 1, 1976·Chest·J M LetteriJ W Ledwith
Sep 1, 1973·Analytical Biochemistry·S C Kuo, E S Younathan
Aug 1, 1974·The Biochemical Journal·S E KnowlesF J Ballard
Aug 1, 1972·The American Journal of Clinical Nutrition·F J Ballard
Mar 28, 1974·The New England Journal of Medicine·A LindnerB H Scribner
Nov 1, 1971·JAMA : the Journal of the American Medical Association·B T BurtonF A Bryan
Jan 1, 1981·American Journal of Nephrology·H F BorgesC M Kjellstrand
Feb 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R W PattersonS F Sullivan
Nov 1, 1982·Artificial Organs·P R Keshaviah
Aug 1, 1961·The Biochemical Journal·F LUNDQUISTH RASMUSSEN
Oct 29, 1960·Nature·I G JARRETT, O H FILSELL
Jan 1, 1962·The British Journal of Nutrition·K L BLAXTER
Feb 10, 1962·Nature·F LUNDQUIST


Jul 30, 1983·British Medical Journal·M A Mansell, A J Wing
Jun 1, 1984·Biomedizinische Technik. Biomedical Engineering·H HamplM Kessel
Jul 1, 1987·Kidney International·J T Daugirdas, Z M Nawab
Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·W E Harmon
Apr 15, 2019·Néphrologie & thérapeutique·Myriam DaoLucile Mercadal

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