Acetazolamide prevents hypoxic pulmonary vasoconstriction in conscious dogs

Journal of Applied Physiology
Claudia HöhneE R Swenson

Abstract

Acute hypoxia increases pulmonary arterial pressure and vascular resistance. Previous studies in isolated smooth muscle and perfused lungs have shown that carbonic anhydrase (CA) inhibition reduces the speed and magnitude of hypoxic pulmonary vasoconstriction (HPV). We studied whether CA inhibition by acetazolamide (Acz) is able to prevent HPV in the unanesthetized animal. Ten chronically tracheotomized, conscious dogs were investigated in three protocols. In all protocols, the dogs breathed 21% O(2) for the first hour and then 8 or 10% O(2) for the next 4 h spontaneously via a ventilator circuit. The protocols were as follows: protocol 1: controls given no Acz, inspired O(2) fraction (Fi(O(2))) = 0.10; protocol 2: Acz infused intravenously (250-mg bolus, followed by 167 microg.kg(-1).min(-1) continuously), Fi(O(2)) = 0.10; protocol 3: Acz given as above, but with Fi(O(2)) reduced to 0.08 to match the arterial Po(2) (Pa(O(2))) observed during hypoxia in controls. Pa(O(2)) was 37 Torr during hypoxia in controls, mean pulmonary arterial pressure increased from 17 +/- 1 to 23 +/- 1 mmHg, and pulmonary vascular resistance increased from 464 +/- 26 to 679 +/- 40 dyn.s(-1).cm(-5) (P < 0.05). In both Acz groups, mean pulmonary arteria...Continue Reading

References

Nov 1, 1978·Respiration Physiology·E R Swenson, T H Maren
Apr 1, 1992·The American Journal of Physiology·J M PostE K Weir
May 1, 1992·Journal of Applied Physiology·J A LoeppkyT W Chick
Apr 1, 1991·The American Journal of Physiology·O MoeW L Henrich
Jun 1, 1991·The American Journal of Physiology·I K Krampetz, R A Rhoades
Jul 1, 1986·Pediatric Pulmonology·J A LindenbergS H Bennett
Dec 1, 1987·Journal of Applied Physiology·B Raffestin, I F McMurtry
Jan 1, 1985·The American Journal of Physiology·J Herget, I F McMurtry
Mar 1, 1993·The American Journal of Physiology·C G Salvaterra, W F Goldman
Jan 1, 1993·Journal of Applied Physiology·E R Swenson, J M Hughes
Apr 1, 1997·Pflügers Archiv : European journal of physiology·D S Ahn, J R Hume
Apr 1, 1997·Journal of Applied Physiology·S C HillierW W Wagner
Aug 5, 1998·The American Journal of Physiology·S A Barman
Sep 24, 1998·The American Journal of Physiology·M G BergerN J Rusch
Jul 29, 1999·Respiration Physiology·J P Ward, P I Aaronson
Aug 13, 1999·The American Journal of Physiology·E SeeligerH W Reinhardt
Oct 16, 1999·General Pharmacology·J P DumasM Dumas
Aug 5, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·J S ShamJ T Sylvester
Nov 15, 2000·Journal of Cardiovascular Pharmacology·F SchwedaB K Krämer
Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·J A MaddenJ G Kleinman
Feb 13, 2001·British Journal of Pharmacology·P PickkersP Smits
Apr 12, 2001·Journal of Applied Physiology·C HöhneG Kaczmarczyk
May 25, 2001·Journal of the American Society of Nephrology : JASN·Erdmann SeeligerH Wolfgang Reinhardt
Apr 19, 2002·Journal of Applied Physiology·Claudia HöhneGabriele Kaczmarczyk
Nov 2, 2002·Progress in Cardiovascular Diseases·Mehran MandegarJason X-J Yuan
Apr 1, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·J Q LiuJ T Sylvester
Mar 26, 2004·Wilderness & Environmental Medicine·John T BergErik R Swenson

❮ Previous
Next ❯

Citations

May 18, 2006·Basic Research in Cardiology·Robert T MalletH Fred Downey
Nov 11, 2006·American Journal of Respiratory and Critical Care Medicine·Luc J TeppemaMarc J Poulin
Apr 5, 2008·American Journal of Respiratory and Critical Care Medicine·Jean-Paul RichaletFabiola León-Velarde
Dec 23, 2008·Wilderness & Environmental Medicine·Joshua O Stream, Colin K Grissom
Jan 8, 2014·Travel Medicine and Infectious Disease·Ken Zafren
Dec 17, 2014·Wilderness & Environmental Medicine·Andrew M LuksPeter H Hackett
Jun 27, 2008·High Altitude Medicine & Biology·Andrew M Luks
Sep 20, 2008·High Altitude Medicine & Biology·Buddha BasnyatErik R Swenson
Feb 24, 2016·The Medical Clinics of North America·Nicholas J Johnson, Andrew M Luks
Jan 28, 2006·The Journal of Physiology·Luc J TeppemaAlbert Dahan
Jan 16, 2007·The Journal of Physiology·Amy M JonkPeter D Wagner
Jul 2, 2010·Wilderness & Environmental Medicine·Andrew M LuksUNKNOWN Wilderness Medical Society
Apr 27, 2010·Progress in Cardiovascular Diseases·Marco Maggiorini
Dec 27, 2005·Respiratory Physiology & Neurobiology·Erik R Swenson
May 25, 2005·European Journal of Pharmacology·Dileep Kumar RohraAnwarul Hassan Gilani
Feb 13, 2003·The Journal of Thoracic and Cardiovascular Surgery·M Grayling, C D Deakin
Sep 2, 2016·High Altitude Medicine & Biology·Enrico DoneganiDavid Hillebrandt
Apr 17, 2018·The Journal of Physiology·Philipp A PickerodtErik R Swenson
Apr 7, 2011·Journal of the Royal Army Medical Corps·D P HallJ K Baillie
Aug 29, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Claudia HöhneErik R Swenson
Jan 9, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Larissa A ShimodaErik R Swenson
May 19, 2010·Expert Review of Respiratory Medicine·Joshua O StreamColin K Grissom
May 1, 2013·British Journal of Pain·Tom Smedley, Michael Pw Grocott
Jul 7, 2007·Journal of Applied Physiology·Vitalie FaoroRobert Naeije
Aug 22, 2015·Journal of Applied Physiology·Erik R Swenson
Feb 14, 2021·International Journal of Environmental Research and Public Health·Akylbek SydykovRalph Theo Schermuly
Nov 3, 2021·Journal of the American Veterinary Medical Association·Katsuhiro MatsuuraYouta Yaginuma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved