PMID: 9426367Jan 14, 1998Paper

Acetonitrile as a possible marker of current cigarette smoking

Human & Experimental Toxicology
P HouetoF J Baud

Abstract

Volatile nitriles are present in cigarette smoke. We tested the hypothesis that the presence of any of four nitriles in the blood can serve as a marker of recent cigarette smoking. We determined the sensitivity and specificity of these nitriles as indicators of daily cigarette smoking in 24 smokers (Group A) and 18 non-smokers (Group B), as well as the correlation between intensity of daily smoking and the blood concentration of acetonitrile. A new head space GLC assay method was used. Of the four nitriles, only acetonitrile was present in the blood of any study subject. Acetonitrile was moderately sensitive (67%) and entirely specific (100%) for self-reported daily smoking. There was fair correlation between blood acetonitrile concentration and the average daily number of cigarettes smoked (r2 = 0.39; P = 0.001), and the mean blood acetonitrile concentration was significantly higher (P = 0.03) among subjects with higher (> 10 cigarettes per day) current cigarette exposure (148.3 +/- 18.0 micrograms/l) than among smokers with low or minimal (1-10 cigarettes per day) exposure (43.3 +/- 6.0 micrograms/l). Thus, acetonitrile in blood appears to be highly specific and a moderately sensitive marker of cigarette smoking with a dose-e...Continue Reading

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Citations

Sep 21, 2012·Chemical Reviews·Meggie HakimHossam Haick
Mar 20, 2004·Wiener klinische Wochenschrift·Philipp LirkWolfgang Schobersberger
Mar 20, 2004·Wiener klinische Wochenschrift·Michael Phillips
Aug 12, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Gerhard Scherer
May 12, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Eduardo Mello De CapitaniJosé Luiz Costa
Oct 21, 2004·Mass Spectrometry Reviews·David Smith, Patrik Spanel
Feb 11, 2012·Parasitology Research·Flávia Aparecida NogueiraEduardo Robson Duarte
May 7, 2015·Journal of Separation Science·Jae KwakDarrin K Ott
Feb 1, 2005·BJU International·Germar-Michael PinggeraJosef Rieder

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