PMID: 4901473Aug 1, 1969Paper

Acetyl CoA carboxylase, II. Deomonstration of biotin-protein and biotin carboxylase subunits

Proceedings of the National Academy of Sciences of the United States of America
A W AlbertsP R Vagelos

Abstract

Previous work has shown that Escherichia coli acetyl CoA carboxylase is composed of two dissimilar protein components, E(a) which contains covalently bound biotin and forms E(a)-CO(2)-from HCO(3)- and ATP, and E(b) which is involved in the transfer of the carboxyl group from E(a)-CO(2)- to acetyl CoA, forming malonyl CoA. E(a) has been dissociated into two subunits at pH 9. One subunit, designated biotin carboxylase, catalyzes a model reaction, the ATP-dependent carboxylation of free (+)-biotin. The other subunit contains covalently bound which is carboxylated by the biotin carboxylase in the course of acetyl CoA carboxylation.

References

Feb 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·A W Alberts, P R Vagelos
Jul 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·E StollM D Lane
Mar 1, 1965·Archives of Biochemistry and Biophysics·K D MUNKRES, F M RICHARDS

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Citations

Jun 20, 1978·Journal of Molecular Evolution·C M Visser, R M Kellogg
Feb 27, 1975·Biochimica Et Biophysica Acta·R R FallP R Vagelos
Jan 1, 1978·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A W Warman, N R Bottino
Jul 18, 2002·Progress in Lipid Research·John E Cronan, Grover L Waldrop
Dec 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·B I GerwinH G Wood
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P DimrothM D Lane
Mar 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R B GuchhaitM D Lane
Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A W AlbertsP R Vagelos
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R R FallP R Vagelos
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KondoT Tanabe
Jun 17, 2010·IUBMB Life·John C Wallace
Apr 1, 1971·Archives of Biochemistry and Biophysics·A M NerviP R Vagelos
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Jun 17, 2021·Microbiology and Molecular Biology Reviews : MMBR·John E Cronan

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