PMID: 6108988Jul 1, 1980Paper

Acetyl-CoA synthesizing enzymes in cholinergic nerve terminals

Journal of Neurochemistry
S H Sterri, F Fonnum

Abstract

The activities of five enzymes involved in acetyl-CoA synthesis, pyruvate dehydrogenase complex, ATP citrate lyase, carnitine acetyltransferase, acetyl-CoA synthetase, and citrate synthase, were determined in normal nucleus interpeduncularis and nucleus interpeduncularis in which cholinergic terminals were removed following lesion of the habenulointerpeduncular tract. The activities of aspartate transaminase, fumarase, and GABA transaminase also were determined to compare the effect of lesion on other mitochondrial enzymes which are not linked to the biosynthesis of ACh. In normal nucleus interpeduncularis the activities of carnitine acetyltransferase and pyruvate dehydrogenase complex were higher than the activity of ChAT (choline acetyltransferase), whereas the activities of acetyl-CoA synthetase and citrate synthase were considerably lower than that of ChAT. The effect of the lesion separated the enzymes into two groups: the activities of pyruvate dehydrogenase complex, carnitine acetyltransferase, fumarase and aspartate transaminase decreased by 30--40%, whereas the activities of the other enzymes descreased 5--15%. ChAT activity was in all cases less than 15% of normal. It could be concluded that none of the acetyl-CoA syn...Continue Reading

References

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Aug 1, 1978·Journal of Neurochemistry·G H Sterling, J J O'Neill
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Citations

Jan 1, 1984·Progress in Biophysics and Molecular Biology·S Tucek
Jan 1, 1993·Progress in Biophysics and Molecular Biology·S Tucek
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C Björkman
Jun 1, 1993·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T FlorioG Schettini
Oct 3, 1998·Brain Research·I ArnulfM Jouvet
Mar 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·Alan J Wolfe
Jun 1, 1990·Neurochemical Research·H L White, P W Scates
Jan 1, 1989·Annals of the New York Academy of Sciences·K F SheuL M Hinman
Feb 24, 2009·Pathology, Research and Practice·Anne Marie LamhonwahIngrid Tein
Aug 5, 2008·Neurochemistry International·Bjørnar HasselAndreas Lossius
Jun 20, 2007·Brain & Development·Anne Marie LamhonwahIngrid Tein
Jan 1, 1985·Journal of Neurochemistry·S Tucek
Jan 21, 2001·The Journal of Biological Chemistry·T FujinoT T Yamamoto
Dec 2, 2019·Endocrine·Alessandra di MasiAndrea Palermo
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S H ChoiY H Suh

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