PMID: 9187536Feb 1, 1997Paper

Acetyl-L-carnitine effects on nerve conduction and glycemic regulation in experimental diabetes

Endocrine Research
I L SoneruC Abraira

Abstract

Acetyl-L-Carnitine (ALC), an activator of carnitine, can accelerate nerve regeneration after experimental surgical injury in rats. In this study, we examined the ability of ALC to improve nerve conduction velocity and its effect on intravenous glucose tolerance test in streptozotocin-induced diabetic rats. Diabetic (blood glucose > 200 mg%) and normal animals were treated intraperitoneally for four weeks with ALC, 50 mg/Kg/d and 150 mg/Kg/d. Nerve conduction velocity was measured by direct exposure of sural nerve. Two-hour IVGTT was studied by measuring plasma glucose, insulin and free fatty acids after intravenous injection of glucose, 1.75 gm/Kg/body weight in animals treated either with ALC 150 md/Kg/d or saline alone. Six weeks of STZ-induced diabetes resulted in impairment of nerve conduction velocity in animals injected with saline (16.05 +/- 1.09 m/s), as compared to saline-treated normals who did not receive streptozotocin (31.0 +/- 0.84 m/s, p<0.0005). Diabetic animals treated with ALC, 150 mg/Kg/d, preserved near normal nerve conduction (27.10 +/- 1.42 m/s), compared with the saline-treated diabetic animals (p < 0.0005), but diabetic animals treated with ALC, 50 mg/Kg/d, had a non-significant increase in nerve conduct...Continue Reading

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Citations

Jul 9, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mahmut CokerDamla Gökşen
Mar 29, 2014·Journal of Physiology and Biochemistry·Ahmed A ElGendy, Amr M Abbas
Feb 21, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ryan BradleyLeanna J Standish
Jun 22, 1999·Experimental Eye Research·S Swamy-Mruthinti, A L Carter

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