Acetyl-L-carnitine prevents total body hydroxyl free radical and uric acid production induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat

Life Sciences
Du Toit LootsCornelis J Van der Schyf

Abstract

Acetyl-L-carnitine (ALCAR) is intimately involved in the transport of long chain fatty acids across the inner mitochondrial membrane during oxidative phosphorylation. ALCAR also has been reported to attenuate the occurrence of parkinsonian symptoms associated with 1-methyl-1,2,3,6-tetrahydropyridine (MPTP) in vivo, and protects in vitro against the toxicity of the neurotoxic 1-methyl-4-phenylpyridinium (MPP+) metabolite of MPTP. The mechanism for these protective effects remains unclear. ALCAR may attenuate hydroxyl (HO*) free radical production in the MPTP/MPP+ neurotoxic pathway through several mechanisms. Most studies on MPTP/MPP+ toxicity and protection by ALCAR have focused on in vivo brain chemistry and in vitro neuronal culture studies. The present study investigates the attenuative effects of ALCAR on whole body oxidative stress markers in the urine of rats treated with MPTP. In a first study, ALCAR totally prevented the MPTP-induced formation of HO* measured by salicylate radical trapping. In a second study, the production of uric acid after MPTP administration-a measure of oxidative stress mediated through xanthine oxidase-was also prevented by ALCAR. Because ALCAR is unlikely to be a potent radical scavenger, these s...Continue Reading

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Citations

Jan 11, 2005·Neurotoxicity Research·Juan Segura Aguilar, Richard M Kostrzewa
Jan 14, 2011·Developmental Neuroscience·Susanna ScafidiGary Fiskum
Mar 23, 2005·European Journal of Nutrition·Catharina Janse van RensburgFrancois H van der Westhuizen
Aug 16, 2008·Renal Failure·Sedat UstundagBora Demirkan
Jun 6, 2015·International Journal of Oncology·Ihsan ElimraniErnest G Seidman
Sep 12, 2006·Experimental Eye Research·P GeraldineP A Thomas

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