Acetyl-L-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats

Annals of the New York Academy of Sciences
Fakhreya Yousuf JalalTimothy J Maher

Abstract

Acetyl-L-carnitine (ALCAR), an endogenous water soluble molecule, is synthesized in the brain and is involved in many aspects of neuronal activity, including metabolism and neuronal membrane formation and integrity. To determine ALCAR's neuroprotective effects, focal cerebral ischemia was induced using four models of middle cerebral artery occlusion (MCAO) and treatment with 0-400 mg/kg ALCAR (i.p.) prior to MCAO. While acute doses were without effect, pretreatment with chronic ALCAR (400 mg/kg/day for five days) significantly reduced infarct size. Lower chronic ALCAR doses were not effective. Additionally, elevations in microdialysate glutamate post-MCAO were attenuated by ALCAR treatment.

References

Dec 7, 1992·Neuroscience Letters·R A Swanson
Nov 1, 1991·Neurology·A SpagnoliM Comelli
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Aug 1, 1988·Journal of Neuroscience Research·L AngelucciR Perez-Polo
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·S T ChenJ D Balentine
Jan 1, 1988·Life Sciences·R G FarielloM DeMattei
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A TamuraG M Teasdale
Feb 15, 1995·Journal of Neuroscience Research·M C Longuemare, R A Swanson
Jan 1, 1994·Journal of Neuroscience Research·G ForloniS Smiroldo
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K TakagiR Busto
Dec 1, 1993·Free Radical Biology & Medicine·Y LiuG Fiskum
Jun 1, 1997·Annals of Emergency Medicine·M M LolicR E Rosenthal
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O PetersU Dirnagl
Feb 5, 1999·Stroke; a Journal of Cerebral Circulation·Y SekiH K Kimelberg
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Dec 31, 2002·Neuropharmacology·Carla GhelardiniAlessandro Bartolini
Oct 23, 2003·Neurochemical Research·Aase Frandsen, Arne Schousboe
Mar 19, 2005·Neuroscience Letters·Robert E RosenthalGary Fiskum
Jun 1, 2005·Brain Research Bulletin·Franciska ErdoFerenc Andrási
Sep 24, 2005·Annals of the New York Academy of Sciences·Santina A ZanelliGary Fiskum
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·S Thomas Carmichael
Nov 24, 2006·Stroke; a Journal of Cerebral Circulation·Kon ChuJae-Kyu Roh
Feb 6, 2007·Brain Research·Marie-Aimée DronneJean-Pierre Boissel
May 25, 2007·Pharmacology, Biochemistry, and Behavior·Aysan Durukan, Turgut Tatlisumak

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Citations

Jan 14, 2011·Developmental Neuroscience·Susanna ScafidiGary Fiskum
Apr 15, 2011·Vascular Health and Risk Management·Carmen MingoranceMaría Dolores Herrera
Nov 23, 2019·Metabolomics : Official Journal of the Metabolomic Society·Chaofu KeYonghong Zhang
Jan 26, 2017·Frontiers in Neuroscience·Tesfaye W Tefera, Karin Borges
Oct 6, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E V Ponomareva
Jul 27, 2018·Scientific Reports·Hui ChenCatherine A Gorrie
Jun 3, 2021·International Journal of Molecular Sciences·Judith WeilandNadine Lilla

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