Abstract
The cellular events involved in acetyl-L-carnitine (ALCAR) analgesia were investigated in the mouse hot plate test. I.c.v. pretreatment with aODNs against the alpha subunit of G(q) and G(11) proteins prevented the analgesia induced by ALCAR (100 mg kg(-1) s.c. twice daily for 7 days). Administration of the phospholipase C (PLC) inhibitors U-73122 and neomycin, as well as the injection of an aODN complementary to the sequence of PLCbeta(1), antagonized the increase of the pain threshold induced by ALCAR. Pretreatment with U-73343, an analogue of U-73112 inactive on PLC, did not modify ALCAR analgesic effect. In mice undergoing treatment with LiCl, which impairs phosphatidylinositol synthesis, or pretreatment with TMB-8, a blocker of Ca(++) release from intracellular stores, the antinociception induced by ALCAR was dose-dependently antagonized. I.c.v. treatment with heparin, an IP(3) receptor antagonist, prevented the increase of pain threshold induced by the investigated compound, analgesia that was restored by co-administration of D-myo-inositol. On the other hand, i.c.v. pretreatment with the selective protein kinase C (PKC) inhibitors calphostin C and cheleritryne, resulted in a dose-dependent potentiation of ALCAR antinocice...Continue Reading
References
Mar 26, 1992·Nature·C D FerrisS H Snyder
Jan 1, 1992·British Journal of Pharmacology·A BartoliniA Giotti
Oct 23, 1992·Science·Y Nishizuka
Mar 17, 1992·European Journal of Pharmacology·S E Smith, B S Meldrum
Apr 11, 1991·Nature·S J TaylorJ H Exton
Nov 15, 1990·Biochemical and Biophysical Research Communications·J M HerbertJ P Maffrand
May 1, 1990·The Biochemical Journal·E D KennedyS R Nahorski
Mar 15, 1989·Biochemical and Biophysical Research Communications·E KobayashiT Tamaoki
Oct 30, 1987·Science·A AshkenaziJ Ramachandran
Mar 1, 1985·Neuropharmacology·J L VaughtS J Enna
Jun 1, 1974·European Journal of Pharmacology·M H Malagodi, C Y Chiou
Jun 1, 1993·Pharmacology & Therapeutics·M P Caulfield
Jan 1, 1995·Diabetologia·A QuatraroD Giugliano
Nov 30, 1994·Biochemical and Biophysical Research Communications·M Phillippe
Jan 1, 1996·Life Sciences·C GhelardiniF Gualtieri
Aug 1, 1997·Clinical Neuropharmacology·B Kores, M H Lader
Oct 10, 1997·Anesthesia and Analgesia·M Naguib, T L Yaksh
Nov 25, 1997·Annals of the New York Academy of Sciences·S JonasR Llinás
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·A I Basbaum
Apr 26, 2000·British Journal of Pharmacology·C GhelardiniA Bartolini
May 2, 2000·Neuroscience Letters·M P JohnsonM Chamberlain
Oct 4, 2000·Physiological Reviews·M J Rebecchi, S N Pentyala
Dec 1, 2000·Progress in Brain Research·A B Malmberg
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·C J Phiel, P S Klein
Nov 8, 2001·European Journal of Pharmacology·M Zimmermann
Jan 5, 2002·Expert Opinion on Investigational Drugs·J KameiL F Tseng
Apr 19, 2002·Molecular Pharmacology·S ChiechioF Nicoletti
Dec 31, 2002·Neuropharmacology·Carla GhelardiniAlessandro Bartolini
May 9, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicoletta GaleottiCarla Ghelardini
Mar 1, 1957·British Journal of Pharmacology and Chemotherapy·T J HALEY, W G MCCORMICK
Citations
Apr 28, 2007·HIV Medicine·M YouleUNKNOWN ALCAR Study Group
Sep 26, 2007·CNS Drugs·Mike Youle
Oct 5, 2015·Inflammation·Fred McMahonKevin Kavanagh
Aug 26, 2010·The Journal of Physiology·Rania E MuftiDonald G Welsh
Jan 11, 2005·Journal of Neuroscience Research·Vittorio CalabreseAnna Maria Giuffrida Stella
Aug 19, 2008·Journal of Neuroscience Research·Lorenzo Di Cesare MannelliAlessandro Bartolini
Aug 24, 2007·The European Journal of Neuroscience·Lorenzo Di Cesare MannelliA Bartolini
Jan 13, 2006·Neuroscience Letters·Sarah J L FlattersGary J Bennett
Nov 21, 2009·Neuroscience·L Di Cesare MannelliA Bartolini
Mar 23, 2010·Neuroscience·E VivoliC Ghelardini
Dec 3, 2014·Neurochemistry International·Giovanna Traina, Rossana Scuri
Aug 24, 2013·Expert Review of Neurotherapeutics·Marco OnofrjAstrid Thomas
Sep 26, 2007·CNS Drugs·Santina ChiechioFerdinando Nicoletti
May 4, 2018·Neural Regeneration Research·Daniele TomassoniAlessandra Pacini
Aug 4, 2021·ACS Chemical Neuroscience·Antonio Espinosa de Los Monteros-ZúñigaAbimael González-Hernández