Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Su-Bin KimKwang Seok Kim

Abstract

Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α) is a potent transcription factor for mitochondrial function, lipid metabolism, and detoxification in a variety of tissues. PGC1α also promotes brain cell proliferation and memory. However, how PGC1α is involved in aging is not well known. In brain endothelial cells, we found that PGC1α knockdown accelerated DNA damage-induced senescence, evidenced by an increase in senescence-associated β-galactosidase-positive cells and a decrease in cell proliferation and adenosine triphosphate production. PGC1α knockdown delayed DNA damage repair mechanisms compared with the wild-type condition as shown by γ-H2AX foci staining assay. Overexpression of PGC1α reduced senescence-associated β-galactosidase-positive cells and increased the proliferation of senescent cells. Although PGC1α protein levels were not decreased, PGC1 acetylation was increased by ionizing radiation treatment and aging. Histone deacetylase 1 (HDAC1) expression was decreased by ionizing radiation treatment and aging, and downregulation of HDAC1 induced acetylation of PGC1α. HDAC1 knockdown affected sirtuin 1 expression and decreased its deacetylation of PGC1α. In the mouse brain cortex, acetylatio...Continue Reading

References

Sep 1, 1992·The British Journal of Radiology·T E Schultheiss, L C Stephens
Jun 1, 1994·Journal of Bioenergetics and Biomembranes·D C Wallace
May 26, 2005·Cardiovascular Research·Inmaculada ValleMaría Monsalve
Apr 17, 2008·Journal of Bioenergetics and Biomembranes·Christophe RocherThierry Letellier
Jun 17, 2009·Molecular and Cellular Biology·Olga MoiseevaGerardo Ferbeyre
Oct 13, 2009·Experimental Gerontology·Danielle Willis-MartinezEstela E Medrano
Feb 13, 2010·The American Journal of Pathology·Xiangling YinPaula Grammas
Jan 8, 2011·Molecular Neurodegeneration·Hong Van B CheHuu Phuc Nguyen
Jan 11, 2011·Biochimica Et Biophysica Acta·Consiglia PacelliTiziana Cocco
Feb 4, 2011·The American Journal of Clinical Nutrition·Pablo J Fernandez-Marcos, Johan Auwerx
Feb 11, 2011·Nature·Ergün SahinRonald A DePinho
Mar 2, 2011·Journal of Alzheimer's Disease : JAD·Loukia KatsouriMagdalena Sastre
Jul 27, 2012·Frontiers in Oncology·Dana Greene-SchloesserMichael D Chan
Jan 18, 2013·Nature·Simon C JohnsonMatt Kaeberlein
Feb 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Shiqin XiongR Wayne Alexander
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Oct 15, 2013·Cell Metabolism·Christiane D WrannBruce M Spiegelman
May 23, 2014·Nature·Jan M van Deursen
Jun 13, 2014·Cell Cycle·Regina M DayRonald Allan M Panganiban
Jun 24, 2014·Nature Reviews. Molecular Cell Biology·Daniel Muñoz-Espín, Manuel Serrano
Oct 5, 2014·Experimental Gerontology·Shankar J ChintaJulie K Andersen
Oct 12, 2014·Biogerontology·Florence C C TanMark P Mattson
Mar 24, 2015·The Journal of Clinical Investigation·Wenjun XiongConstance L Cepko
Nov 28, 2015·Neuromolecular Medicine·Mohammad Jodeiri FarshbafMohammad Hossein Nasr-Esfahani
Feb 15, 2016·Trends in Biochemical Sciences·Suchira Gallage, Jesús Gil
Nov 11, 2016·Nature·Tony Wyss-Coray

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Citations

Dec 25, 2019·Cellular and Molecular Life Sciences : CMLS·Justin B Collier, Rick G Schnellmann
Mar 28, 2020·Antioxidants & Redox Signaling·Riva Shmulevich, Valery Krizhanovsky
Jun 3, 2021·International Journal of Molecular Sciences·Bibiana C Mota, Magdalena Sastre
Jul 16, 2021·Cardiovascular Research·Luke S Dunaway, Jennifer S Pollock
Aug 31, 2021·Radiation Research·Haoren QinHui Wang

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