PMID: 108703Feb 28, 1979

Acetylation of phenelzine

Psychopharmacology
W J TilstoneE C Johnstone

Abstract

Microsome-free preparations of rodent and human liver were shown to contain N-acetyl transferase from experiments using procainamide as substrate. These preparations then acetylated phenelzine from the quantitative transfer of radiolabeled acetate. This in vitro demonstration of phenelzine acetylation in rodent and human liver was corroborated by the finding of a negative correlation between excretion of phenelzine in urine and sulphadimidine acetylation in 27 patients.

References

Dec 1, 1978·European Journal of Clinical Pharmacology·W J TilstoneT D Lawrie
Oct 2, 1976·British Medical Journal·E F Marshall
Mar 17, 1973·Lancet·E C Johnstone, W Marsh
Mar 1, 1971·JAMA : the Journal of the American Medical Association·J Koch-Weser, S W Klein
Jul 1, 1969·The Biochemical Journal·T A WhiteD A Evans
Jul 1, 1965·Clinical Pharmacology and Therapeutics·D A EvansR T PRATT
Aug 1, 1976·British Journal of Clinical Pharmacology·B CaddyE C Johnstone

Citations

May 1, 1979·British Journal of Clinical Pharmacology·G L Sanders, M D Rawlins
Aug 1, 1991·Journal of Pharmaceutical Sciences·R T CouttsG B Baker
May 1, 1989·Archives of Biochemistry and Biophysics·L C Leite, O Augusto
Apr 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·P TyrerM Whitford
May 17, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Stephen C Mitchell
Jun 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·C M Pare
Sep 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·E S PaykelR R Parker

Related Concepts

Acetyl Coenzyme A
Acetylation
Acetyltransferase
Metazoa
Liver
Nardelzine
Rhythmin
Rats, Laboratory
In Vitro [Publication Type]

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