PMID: 5386195Jul 1, 1969

Acetylation of serotonin in vitro by a human N-acetyltransferase

The Biochemical Journal
T A WhiteD A Evans

Abstract

1. There is a well-recognized genetic polymorphism for the N-acetylation of isoniazid and sulphamethazine by human livers. 2. Serotonin was found to be acetylated by human liver enzyme preparations and the N-acetylserotonin formed was identified and determined quantitatively. 3. In 13 livers examined there was a wide variability in the capacity to acetylate serotonin that did not correlate with the capacity of the same livers to acetylate isoniazid and sulphamethazine. The results suggest that serotonin is not a natural substrate for the polymorphic N-acetyltransferase and that it may be acetylated by a different enzyme.

Citations

Jul 6, 1971·Annals of the New York Academy of Sciences·W Kalow
Jan 1, 1970·Humangenetik·W Schloot, H W Goedde
Feb 28, 1979·Psychopharmacology·W J TilstoneE C Johnstone
Nov 27, 2019·Journal of Pineal Research·A SlominskiDesmond J Tobin

Related Concepts

Acyltransferase
Tubazide
Liver
Genetic Polymorphism
Hydroxytryptamine
Sulfamethazine

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