Acetylation of Sirt2 by p300 attenuates its deacetylase activity

Biochemical and Biophysical Research Communications
Younho HanKwang-Youl Lee

Abstract

Histone deacetylases (HDACs) are subdivided into three classes--HDAC I, HDAC II, and Sir2. Sirt proteins are mammalian members of the Sir2 family of NAD+ (nicotinamide adenine dinucleotide)-dependent protein deacetylases. The balance between acetylation and deacetylation of histone and non-histone proteins, regulated by protein acetyltransferases and deacetylases, affects the expression of genes involved in a variety of cellular processes. In addition, HDAC1 is acetylated and regulated by p300, a transcriptional co-activator with protein acetyltransferase activity, suggesting that protein acetyltransferases and deacetylases they control the activities of each other. Although the regulation of HDAC1 by p300 is well characterized, the relationship between Sir2 homologs and p300 is not understood. Here, we report that p300 interacts with Sirt2, a member of the Sir2 family, and triggers the acetylation and subsequent down-regulation of the deacetylation activity of Sirt2, and that the acetylation of Sirt2 by p300 relieves the inhibitory effect of Sirt2 on the transcriptional activity of p53. These observations demonstrate that p300 can inactivate Sirt2 by acetylation and that p300 may regulate the activity of p53 indirectly through...Continue Reading

References

Mar 4, 2000·Nature Genetics·S A GaytherC Caldas
Mar 16, 2000·The EMBO Journal·T Kouzarides
Mar 7, 2003·Molecular Cell·Brian J NorthEric Verdin
Mar 22, 2003·Current Opinion in Cell Biology·Christopher L Brooks, Wei Gu
Jan 27, 2004·Journal of Leukocyte Biology·Stephen W BuckJeffrey S Smith
Feb 18, 2004·Oncogene·Cristiano SimonePier Lorenzo Puri
Feb 26, 2004·Cell·Maria Carla MottaLeonard Guarente
Jun 11, 2004·Annual Review of Biochemistry·Gil Blander, Leonard Guarente
Oct 28, 2004·Biochemical Society Transactions·R Marmorstein
Dec 8, 2004·Archives of Biochemistry and Biophysics·Marcy Hernick, Carol A Fierke
Feb 6, 2008·Biochemical and Biophysical Research Communications·Yun-Hye JinKwang-Youl Lee

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Citations

Aug 24, 2011·Molecular Neurobiology·Claire JacobUeli Suter
Jan 15, 2011·Journal of Biomedicine & Biotechnology·Ya-Li Yao, Wen-Ming Yang
Sep 14, 2011·Journal of Biomedicine & Biotechnology·Ramkumar RajendranConstantinos Demonacos
Jul 31, 2013·Biochimica Et Biophysica Acta·Daoyong ZhangJerry L Workman
Jun 18, 2010·Expert Review of Anticancer Therapy·Brahma N SinghShi-Wen Jiang
Mar 5, 2013·Journal of Structural Biology·Sébastien MoniotClemens Steegborn
Oct 30, 2012·Free Radical Biology & Medicine·Brian J Morris
May 26, 2012·Metabolism: Clinical and Experimental·Nima AlamdariPer-Olof Hasselgren
Dec 17, 2009·European Journal of Cell Biology·Kai Harting, Bernd Knöll
Nov 10, 2010·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yanze LiToshiaki Inoue
Oct 8, 2009·International Journal of Cancer. Journal International Du Cancer·Li KaiAnait S Levenson
Dec 9, 2014·Cell Cycle·Melissa J WilkingNihal Ahmad
Apr 13, 2013·Biochimica Et Biophysica Acta·Pedro Guedes-Dias, Jorge M A Oliveira
Nov 2, 2013·Journal of Molecular Biology·Johannes G M RackMathias Ziegler
Mar 8, 2013·Autophagy·Agnes BánrétiYacine Graba
Apr 7, 2009·Biochemical and Biophysical Research Communications·Younho HanKwang-Youl Lee
Jun 29, 2013·Biochemical and Biophysical Research Communications·You Hee ChoiKwang Youl Lee
Jul 6, 2014·Biochemical and Biophysical Research Communications·You Hee ChoiKwang Youl Lee
Dec 15, 2010·Journal of Biomedicine & Biotechnology·Alessia Peserico, Cristiano Simone
Oct 7, 2014·Biochemical and Biophysical Research Communications·You Hee ChoiKwang Youl Lee
May 7, 2016·Cell Cycle·Hui ZhangDavid S Yu
May 28, 2016·Clinical Epigenetics·Hannah Wapenaar, Frank J Dekker
Nov 6, 2015·Trends in Pharmacological Sciences·Pedro GomesCláudia Cavadas
Jun 30, 2016·The Biochemical Journal·Karin Sadoul, Saadi Khochbin
Sep 4, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcin BulerJukka Hakkola
Sep 11, 2019·Ageing Research Reviews·Yan WangLili Cui
Jan 14, 2021·International Journal of Molecular Sciences·Ewa Maria KratzAgnieszka Piwowar
Aug 24, 2010·The Journal of Physical Chemistry. B·Zhongjie LiangHualiang Jiang
Aug 26, 2021·Biological Chemistry·Anna-Theresa BlaslMichael Lammers
Feb 1, 2018·ACS Chemical Biology·Elysian GrahamYana Cen
Oct 14, 2010·Cellular Signalling·Daniel PerdizAnita Baillet

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