Acetylator phenotype and lupus erythematosus

Clinical Pharmacokinetics
J Uetrecht, R L Woosley

Abstract

There are several known therapeutic implications of acetylator phenotype; among them, the association of a higher incidence of procainamide- and hydralazine-induced lupus in slow acetylators. Presumably, this is because acetylation of the aromatic amine or hydrazine functional group leads to a non-toxic product. Several other drugs which have been implicated in drug-induced lupus also contain an aromatic amine or hydrazine group. The clinical and laboratory characteristics of drug-induced and idiopathic lupus are similar but the degree to which the pathophysiological mechanisms are related, if at all, is unknown. There is also evidence reported for an association between the slow acetylator phenotype and idiopathic lupus. If true, this relationship should provoke some new experimental approaches to investigation into the mechanism of idiopathic lupus.

Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·O Paulsen, L G Nilsson
Jan 1, 1985·European Journal of Clinical Pharmacology·J R MarsdenS Shuster
Jan 1, 1983·European Journal of Clinical Pharmacology·W A Bogers, L Meems
Jun 15, 2010·Clinical Rheumatology·Bruce Rothschild
Jun 19, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Roberto TrottaLicia Iacoviello
Apr 11, 1997·Toxicology·J P Uetrecht
Jun 27, 1998·Clinics in Dermatology·K D Pramatarov
Mar 12, 2013·Pharmacological Reviews·Jack Uetrecht, Dean J Naisbitt
Jun 12, 1999·Annals of the Rheumatic Diseases·S KortunayS O Kayaalp
Aug 2, 2006·Annual Review of Pharmacology and Toxicology·Jack Uetrecht
Dec 1, 2009·Future Medicinal Chemistry·Stephanie KadowCharlotte Esser
Apr 26, 2003·The Journal of Investigative Dermatology·Dagmar Richter-HintzCharlotte Esser
Dec 1, 1983·The American Journal of Medicine·M M Reidenberg
Jan 1, 1984·Annals of the New York Academy of Sciences·M M Reidenberg
Jun 9, 2005·Journal of Hypertension·Philip B Mellen, David M Herrington
Nov 26, 2009·Chemistry & Biodiversity·Charlotte Esser, Bettina Jux
Feb 24, 2001·Journal of Hypertension·S T TurnerE Boerwinkle
Jan 1, 1982·Acta Pharmacologica Et Toxicologica·H Olsen
Aug 1, 1981·Arthritis and Rheumatism·J P UetrechtR L Woosley
Jan 20, 2009·Chemical Research in Toxicology·Jack Uetrecht
May 22, 2021·Pharmacological Reviews·Samantha Christine SernoskieJack Paul Uetrecht

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