PMID: 8584200Aug 11, 1995Paper

Acetylcholine activates a nicotinic receptor and an inward current in dorsal motor nucleus of the vagus neurons in vitro

Neuroscience Letters
Robert NeffD Mendelowitz

Abstract

This study examines the effect of acetylcholine (Ach) on parasympathetic vagal neurons in the dorsal motor nucleus of the vagus (DMNX). Patch-clamp techniques were utilized to examine voltage and ligand-gated currents in visualized DMNX neurons in an in vitro slice. Ach (100 microM) activated an inward current, -196.4 +/- 56.9 pA at -80 mV (n = 15) that was accompanied by a decrease in membrane resistance of 48.6 +/- 9.2% in a population of DMNX neurons. The reversal potential for this ligand-gated current was -11.3 +/- 11.5 mV. The specific agonist nicotine (200 microM) elicited similar responses. Nicotine decreased membrane resistance by 60.9 +/- 4.3% and activated an inward current (-215.7 +/- 45.7 pA at -80 mV) that reversed at -12.7 +/- 20.4 mV (n = 16). Bethanecol (100 microM), a specific muscarinic agonist, had no effect. Neither Ach or nicotine had any effect on the voltage-gated sodium and outward potassium currents present in these neurons.

References

Jul 22, 1992·Proceedings. Biological Sciences·P Sah, E M McLachlan
Aug 1, 1987·Journal of the Autonomic Nervous System·R L StornettaR C McCarty
Apr 1, 1972·The Journal of Physiology·D L Kunze
Feb 1, 1972·Circulation Research·T G PickeringP Sleight
Oct 28, 1982·Brain Research·J V Halliwell, P R Adams
Jul 17, 1981·Neuroscience Letters·A Constanti, D A Brown

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Citations

Jan 24, 2014·Obesity Research & Clinical Practice·Hirotaka UedaAkio Inui
Aug 14, 2008·The Journal of Comparative Neurology·Kathryn T O'LearyFrances M Leslie

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