PMID: 5260928Aug 1, 1969Paper

Acetylcholine and its thiolester and selenolester analogs: conformation, electron distribution, and biological activity

Proceedings of the National Academy of Sciences of the United States of America
E Shefter, H G MAUTNER


The crystal structures of acetylthiolcholine bromide and propionylthiolcholine iodide were elucidated. Acetylthiolcholine was found to be essentially isosteric with acetylselenolcholine, while the conformation of these compounds was quite different from that of acetylcholine. The importance of conformation and electron distribution in the biological actions of choline esters is discussed.


Apr 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·P RosenbergD Nachmansohn
Jan 1, 1968·Journal of Pharmaceutical Sciences·E Shefter
Apr 28, 1968·Journal of Molecular Biology·A M LiquoriJ L De Coen
Sep 16, 1966·Science·E Shefter, O Kennard
Mar 24, 1967·Science·P Rosenberg, H G MAUTNER
Mar 1, 1967·Journal of the American Chemical Society·E Shefter, H G MAUTNER
Mar 1, 1964·Journal of Medicinal Chemistry·W H GUENTHER, H G MAUTNER


Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A MakriyannisH G MAUTNER
Apr 17, 1972·Annals of the New York Academy of Sciences·H G MAUTNER
Sep 1, 1971·Journal of Pharmaceutical Sciences·E Shefter, E E Smissman
Apr 16, 1971·Nature·R W BakerT J Petcher
Oct 20, 1971·Nature: New Biology·F ContiN Russo
Jul 19, 1972·Nature: New Biology·H G MAUTNERB W Low

Related Concepts

Acetilcolina Cusi
X-Ray Diffraction

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.