Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease

European Journal of Nuclear Medicine and Molecular Imaging
Karl Herholz

Abstract

Impairment of cholinergic neurotransmission is a well-established fact in Alzheimer's disease (AD), but there is controversy about its relevance at the early stages of the disease and in mild cognitive impairment (MCI). In vivo positron emission tomography imaging of cortical acetylcholine esterase (AChE) activity as a marker of cholinergic innervation that is expressed by cholinergic axons and cholinoceptive neurons has demonstrated a reduction of this enzyme activity in manifest AD. The technique is also useful to measure the inhibition of cerebral AChE induced by cholinesterase inhibitors for treatment of dementia symptoms. A reduction of cortical AchE activity was found consistently in all studies of AD and in few cases of MCI who later concerted to AD. The in vivo findings in MCI and very mild AD are still preliminary, and studies seem to suggest that cholinergic innervation and AChE as the main degrading enzyme are both reduced, which might result in partial compensation of their effect.

References

Jul 1, 1978·Neuropathology and Applied Neurobiology·E K PerryB E Tomlinson
Dec 1, 1990·Journal of Neuroscience Research·K J ReinikainenP J Riekkinen
Oct 28, 1998·Journal of Physiology, Paris·N C Inestrosa, R Alarcón
Apr 22, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L TraykovS Pappata
Apr 27, 1999·JAMA : the Journal of the American Medical Association·K L DavisV Haroutunian
Jun 4, 1999·Trends in Neurosciences·E PerryR Perry
Oct 26, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A KoeppeD E Kuhl
Jun 13, 2000·Alzheimer Disease and Associated Disorders·H ShinotohT Irie
Feb 15, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S E SnyderD E Kuhl
May 19, 2001·European Journal of Nuclear Medicine·K HerholzW D Heiss
Nov 10, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S Nagatsuka SiT Irie
Nov 28, 2002·Journal of Clinical Psychopharmacology·Valtteri KaasinenJuha O Rinne
Dec 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J O RinneT Kurki
May 12, 2004·Current Pharmaceutical Design·Hitoshi ShinotohToshiaki Irie
Jun 8, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Koichi SatoToshiaki Irie
Aug 20, 2005·Neuroreport·Karl HerholzWolf-Dieter Heiss
Sep 26, 2006·Neuroscience Letters·Carsten EggersWolf-Dieter Heiss

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Citations

Dec 10, 2013·Journal of Molecular Neuroscience : MN·María-Letizia CampanariJavier Sáez-Valero
Nov 12, 2013·Environmental Toxicology and Pharmacology·Svetlana Vučetić-ArsićNataša D Petronijević
Oct 21, 2010·European Archives of Psychiatry and Clinical Neuroscience·Frank JessenWolfgang Maier
Mar 31, 2009·Expert Opinion on Drug Delivery·J RipA G de Boer
May 5, 2016·Journal of Medicinal Chemistry·Reem AlshehriAdnan Memic
Oct 22, 2016·Advanced Pharmaceutical Bulletin·Shringika SoniBikash Medhi
Jun 29, 2017·Journal of Cellular and Molecular Medicine·Yue WangJian-Zhi Wang
Oct 31, 2012·International Journal of Molecular Sciences·Koji Aoyama, Toshio Nakaki
Nov 26, 2013·Journal of Neuroscience Research·Pengwen WangShucui Jiang
Nov 17, 2014·Metabolic Brain Disease·Zhiyou CaiLiang-Jun Yan
Jan 15, 2018·Journal of Alzheimer's Disease : JAD·P Hemachandra ReddyArubala P Reddy
May 10, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jeffrey L Cummings
Jan 9, 2018·Brain : a Journal of Neurology·Nils RichterJuraj Kukolja
Dec 16, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe TardioloEmanuela Mazzon
May 16, 2018·Frontiers in Pharmacology·Abadi Kahsu GebreDerbew Fikadu Berhe
Sep 17, 2020·Molecular Neurobiology·Md Sahab UddinMohamed M Abdel-Daim
Feb 19, 2019·Journal of Alzheimer's Disease : JAD·Tobore Onojighofia Tobore
Nov 26, 2020·Cells·Maria Calvo-RodriguezBrian J Bacskai
Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin-Xiu GuoTie-Jie Wang
Oct 28, 2019·Molecular and Cellular Neurosciences· Sushma, Amal Chandra Mondal
Nov 30, 2020·Psychoneuroendocrinology·Ashutosh AhireB N Srikumar
Jan 28, 2021·Journal of Medicinal Chemistry·Nerella Sridhar GoudPardeep Kumar
Oct 28, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sajini D HettiarachchiRoger M Leblanc

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