Acetylcholine promotes progesterone-induced maturation of Xenopus oocytes

The Journal of Experimental Zoology
N DascalY Oron

Abstract

Progesterone-induced maturation of follicle-enclosed and denuded Xenopus laevis oocytes was significantly shortened by a concomitant exposure to acetylcholine. The promotion of maturation by acetylcholine was blocked by the specific muscarinic antagonist atropine. The action of acetylcholine was dose dependent, and the neurotransmitter was effective at very low concentrations. Progesterone progressively reduced the electrophysiological responses of X. laevis oocytes to acetylcholine, which completely disappeared close to the time of germinal vesicle breakdown. Progesterone alone did not elicit any electrophysiological responses. The in vitro effect of acetylcholine on oocyte maturation might reflect a physiological influence of the cholinergic system on an in vivo maturation process.

References

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Citations

Mar 1, 1992·Pflügers Archiv : European journal of physiology·G GoldbergY Oron
Aug 1, 1987·Pflügers Archiv : European journal of physiology·N Dascal, S Cohen
Jul 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·T S AlonsoF J Barrantes
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S D KrollR Iyengar
Sep 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R M Woodward, R Miledi
Jun 16, 2000·The Journal of Physiology·A L Pérez-SamartínR O Arellano
Dec 3, 1999·The Journal of Physiology·R O ArellanoR Miledi
Jan 1, 1987·CRC Critical Reviews in Biochemistry·N Dascal
May 19, 2004·British Journal of Pharmacology·Sang Min JeongSeung-Yeol Nah
Jan 1, 1987·Journal of Biochemical Toxicology·D W Bombick, F Matsumura
Apr 1, 1989·The Journal of Experimental Zoology·J P VilainM Moreau
Nov 11, 1990·The American Journal of Physiology·L J GreenfieldJ Linden

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