PMID: 6973710Aug 1, 1981Paper

Acetylcholine receptor antibody synthesis by thymic lymphocytes: correlation with thymic histology

Neurology
G K ScaddingK Henry

Abstract

Antiacetylcholine receptor antibody (anti-AChR) was spontaneously synthesized by cultured thymic tissue from 19 of 35 patients with myasthenia gravis. Two other thymus cultures produced antibody after stimulation by pokeweed mitogen. Antibody production correlated with histologic evidence of thymitis, long duration of symptoms, or high serum anti-AChR values. None of seven thymomas synthesized antibody in culture, but evidence suggested that there had been in vivo synthesis or trapping of anti-AChR. Clinical improvement after thymectomy, during the short period of study, did not correlate with synthesis rates of anti-AChR production by the removed thymus. The rates of anti-AChR production in culture were too low to suggest that the thymus is the major source of this antibody. Although we did not find a clear relationship between anti-AChR antibody and clinical state within 3 months of thymectomy, in a study of 25 nonimmunosuppressed, nonthymoma patients followed for 1 to 4 years, we found a significant correlation (p less than 0.05, Spearman Rank correlation) between fall in anti-AChR antibody and clinical improvement after thymectomy (unpublished observations).

Citations

Jan 15, 1987·Klinische Wochenschrift·W J HofmannH F Otto
Jan 1, 1982·Springer Seminars in Immunopathology·M E Seybold, J M Lindstrom
Dec 1, 1983·Italian Journal of Neurological Sciences·H J Oosterhuis
Feb 1, 1989·Italian Journal of Neurological Sciences·V D'AndreaV Ambrogi
Jan 1, 1988·Immunologic Research·S Berrih-AkninJ F Bach
Jan 29, 2010·Surgery Today·Meinoshin OkumuraHiroyuki Shiono
Sep 1, 1990·Journal of Neuroimmunology·S Nelson, B M Conti-Tronconi
Jan 1, 1992·Clinical Neurology and Neurosurgery·N WakataM Kinoshita
Dec 1, 1988·Brain, Behavior, and Immunity·A Vincent
Jan 1, 1994·Advances in Neuroimmunology·R Hohlfeld, H Wekerle
Apr 1, 1997·Journal of Neuroimmunology·R AhlbergA K Lefvert
Oct 18, 1984·The New England Journal of Medicine·Y Shoenfeld, R S Schwartz
Jun 23, 1994·The New England Journal of Medicine·D B Drachman
Nov 1, 1988·The Journal of Experimental Medicine·S A MichieR V Rouse
Mar 1, 2001·Journal of Clinical Neuromuscular Disease·M Rubin
May 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·L DurelliL Bergamini
Aug 1, 1993·The Journal of Clinical Investigation·A A ManfrediB M Conti-Tronconi
Apr 27, 2013·The Journal of Clinical Investigation·Xuezhi DaiDavid J Rawlings
Dec 1, 1991·Italian Journal of Neurological Sciences·M F FerrioL Bergamini
Jan 1, 1993·Immunologic Research·Y M Graus, M H De Baets
Jun 1, 1986·Journal of Neuroimmunology·L S KlavinskisJ Newsom-Davis
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T KirchnerH K Müller-Hermelink
Jun 21, 1993·Annals of the New York Academy of Sciences·S Ragheb, R P Lisak
Apr 21, 2009·Lancet Neurology·Matthew N Meriggioli, Donald B Sanders
Sep 10, 2008·Pharmacology, Biochemistry, and Behavior·Francisco de Sousa Nogueira-NetoYara Cury
Nov 23, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wataru IshiiShu-Ichi Ikeda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.