PMID: 6977352Feb 1, 1982Paper

Acetylcholine receptor antibody titer and HLA-B8 antigen in myasthenia gravis

Archives of Neurology
J KeeseyR Walford

Abstract

In 82 white patients with myasthenia gravis, a high serum human acetylcholine receptor (AChR) antibody titer was related to the presence of the HLA-B8 antigen and increasing severity of the disease and not to age at onset, sex, presence of thymoma, or mode of treatment. Among patients without thymomas a high antibody titer was also associated with HLA-B8, particularly in those patients whose age at onset was less than 35 years. Thymectomy was associated with a lower median antibody titer when compared in two groups of HLA-B8-positive patients without thymoma who were similar for all other factors. Patients with thymomas who had received corticosteroids had a lower median titer than those who had not received steroids. This study supports the possibility that immune-response genes near the HLA-B8 segment of the major histocompatibility complex participate in the regulation of the humoral response to autoantigens, such as AChR protein.

Citations

Jan 1, 1982·Springer Seminars in Immunopathology·M E Seybold, J M Lindstrom
Sep 11, 2002·Journal of the Neurological Sciences·M De Baets, M H W Stassen
Mar 24, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Ryan RamanujamLennart Hammarström
Jan 1, 1984·Epilepsia·O Dulac, M Arthuis
Jun 1, 1987·Acta Neurologica Scandinavica·S ThorlaciusH Hofstad
Jan 29, 1983·British Medical Journal·M J GarleppF T Christiansen
Mar 1, 1990·Arquivos de neuro-psiquiatria·E Dias-TostaJ A Villaça

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