PMID: 8971804Nov 29, 1996Paper

Acetylcholine release from rat brain cortical slices evoked by the fraction P4 of the venom of the spider Phoneutria nigriventer has Ca2+ and temperature independent components

Neuroscience Letters
M A Romano-SilvaA M Ribeiro

Abstract

Fractionation of the venom of the spider Phoneutria nigriventer revealed that it was a mixture of several neurotoxic peptides. The peptides so far characterized either inhibited or induced neurotransmitter release. These effects were mediated by Ca2+ channels or increasing Na+ permeability through voltage sensitive Na(+)-channels, respectively. The pooled toxic components (fraction P4) showed stimulatory effects on acetylcholine release from brain cortical slices. In addition, a component of the observed effects resembling that of alpha-latrotoxin was identified, which was characterized by the ability to provoke release of acetylcholine (ACh) at low temperature and in a manner independent of extracellular Ca2+ and of voltage sensitive Na(+)-channels.

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Citations

Dec 7, 2002·Toxicon : Official Journal of the International Society on Toxinology·Evanguedes KalapothakisAlvair Pinto de Almeida
Aug 26, 1999·Pharmacology, Biochemistry, and Behavior·S TanabeT Yokokura
Dec 5, 1998·Toxicon : Official Journal of the International Society on Toxinology·E KalapothakisV F Prado
Feb 27, 2001·Toxicon : Official Journal of the International Society on Toxinology·C KushmerickM A Prado
Dec 5, 1998·Toxicon : Official Journal of the International Society on Toxinology·E KalapothakisP S Beirão
Feb 6, 2004·Toxicon : Official Journal of the International Society on Toxinology·Leida Calegário OliveiraSuely G Figueiredo
Nov 14, 1997·British Journal of Pharmacology·C GuatimosimM A Prado
May 15, 2007·Brain Research Bulletin·Maria Alice da Cruz-HöflingCatarina Rapôso

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