PMID: 8951440Nov 1, 1996Paper

Acetylcholine response in guinea pig outer hair cells. I. Properties of the response

Hearing Research
A P NenovR P Bobbin

Abstract

The properties of the ACh (acetylcholine) response in guinea pig outer hair cells (OHCs) are not well understood. It has been shown that the response to ACh involves the activation of a Ca2+ dependent K+ selective conductance (referred to as Ksub where sub stands for suberyldicholine). In the present study, we examined the voltage dependence, the time dependence, and the desensitization of the ACh response. In addition, we examined the K+ selectivity of K(sub). These properties are important for aiding in the determination of the type of K+ channels activated by ACh. Patch-clamp technique in the whole-cell mode was used to record from single OHCs isolated from adult pigmented guinea pigs. ACh (100 microM) was applied to the voltage-clamped OHCs and the ACh induced currents (IACh) were measured. A voltage dependence of the ACh response was found with the ACh induced currents decaying monoexponentially at potentials positive to -30 mV. The decay of the ACh induced currents was faster soon after establishing the whole-cell mode of recording when compared to the decay of the currents some time later. This effect, referred to as the time dependence, was different from the desensitization of the response upon prolonged application of...Continue Reading

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Citations

May 4, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·T M MatthewsP A Fuchs
Nov 1, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qi YaoWeijia Kong
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jimena BallesteroEleonora Katz
Jun 26, 1998·British Journal of Pharmacology·C Chen, R P Bobbin
Sep 22, 2010·Journal of the American Chemical Society·Keary M EngleJin-Quan Yu
Apr 26, 2013·International Journal of Molecular Sciences·Tao ZhouWei-Jia Kong
Apr 30, 2005·The Journal of Physiology·María Eugenia Gómez-CasatiEleonora Katz
Nov 24, 1999·The American Journal of Physiology·T van Den AbbeeleP T Huy
Dec 5, 2017·Frontiers in Cellular Neuroscience·Xiaorong Xu ParksJoseph C Holt
Jul 19, 2011·Journal of Physiology, Paris·Ana Belén Elgoyhen, Eleonora Katz

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