PMID: 5914249Sep 1, 1966

Acetylcholine sensitivity of cerebellar neurones in the cat

The Journal of Physiology
J M CRAWFORDV J Wilson

Abstract

1. Cholinomimetics, acetylcholine antagonists and some other compounds of pharmacological interest were administered electrophoretically near neurones within the vermal cerebellar cortex of anaesthetized (pentobarbitone) and unanaesthetized (cerveau isolé) cats.2. The neurones were identified by position within the cortex, spontaneous activity, and the responses to afferent and antidromic stimulation.3. Purkinje cells, but neither granule nor basket cells, were excited by cholinomimetics, and the acetylcholine receptors had muscarinic properties. Excitation was often preceded by depression of the spontaneous firing.4. Intravenously administered atropine and dihydro-beta-erythroidine did not depress the synaptic excitation of cerebellar neurones evoked by impulses in mossy, climbing or parallel fibres.5. Acetylcholine is thus unlikely to be an excitatory transmitter within the feline cerebellum, particularly at mossy fibre-granule cell synapses, despite the presence of relatively high levels of acetylcholinesterase within mossy fibre terminals.

Citations

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Jan 1, 1972·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·W J Brown, S L Palay
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Apr 26, 1974·Brain Research·D R CurtisR M McCulloch
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Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lorenzo Rinaldo, Christian Hansel
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Related Concepts

Acetylcholine Sulfate (1: 1)
Atropen
Felis catus
Cerebellar Cortex Structure
Pedameth
Muscle
Neurons
Synapses

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