PMID: 5914249Sep 1, 1966

Acetylcholine sensitivity of cerebellar neurones in the cat

The Journal of Physiology


1. Cholinomimetics, acetylcholine antagonists and some other compounds of pharmacological interest were administered electrophoretically near neurones within the vermal cerebellar cortex of anaesthetized (pentobarbitone) and unanaesthetized (cerveau isolé) cats.2. The neurones were identified by position within the cortex, spontaneous activity, and the responses to afferent and antidromic stimulation.3. Purkinje cells, but neither granule nor basket cells, were excited by cholinomimetics, and the acetylcholine receptors had muscarinic properties. Excitation was often preceded by depression of the spontaneous firing.4. Intravenously administered atropine and dihydro-beta-erythroidine did not depress the synaptic excitation of cerebellar neurones evoked by impulses in mossy, climbing or parallel fibres.5. Acetylcholine is thus unlikely to be an excitatory transmitter within the feline cerebellum, particularly at mossy fibre-granule cell synapses, despite the presence of relatively high levels of acetylcholinesterase within mossy fibre terminals.


Sep 1, 1967·International Journal of Neuropharmacology·D Satinsky
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Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lorenzo Rinaldo, Christian Hansel
Jan 1, 1970·British Journal of Pharmacology·A K Tebecis
May 27, 1967·Nature·T J Biscoe, D R Curtis
Dec 5, 1970·Nature·W H Beers, E Reich
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Aug 26, 2016·Reviews in the Neurosciences·Changzheng ZhangTifei Yuan
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Aug 1, 1977·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J W Phillis

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