Acetylcholine stimulates insulin, glucagon, and somatostatin release in the perfused chicken pancreas

Endocrinology
R N Honey, G C Weir

Abstract

To evaluate the possible cholinergic control of islet hormone secretion, acetylcholine (10 microM) was perfused into the isolated chicken pancreas-duodenum, with perfusate concentrations of 2.8, 14, or 42 mM glucose. Prompt and significant stimulation of insulin, glucagon, and somatostatin secretion was seen when the glucose concentration was 14 mM, and this stimulation was blocked by preinfusion of atropine sulfate (50 microM). Similar stimulation of all three peptides was seen when the perfusate concentration of glucose was 42 mM. When the perfusate glucose concentration was 2.8 mM, the insulin response to acetylcholine was absent and the response by glucagon could not be discerned, perhaps because release was close to maximal. The somatostatin response, however, was only slightly diminished from that seen at higher glucose levels. The B cell response to acetycholine in the chicken was considerably greater than the weak responses seen to high glucose or arginine, suggesting a dominant role for cholinergic control of avian insulin secretion. In addition, the parasympathetic nervous system may also play a role in the secretory control of A- and D cells.

Citations

Dec 22, 2007·In Vitro Cellular & Developmental Biology. Animal·A MaraisB Kramer
Jul 1, 1985·Metabolism: Clinical and Experimental·G A WilliamsW J Henderson
Dec 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·N Rideau, J Simon
Dec 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·N Rideau, J Simon
May 30, 2001·Nutrition·U N Das
Jun 25, 1981·The New England Journal of Medicine·R H Unger, L Orci
Mar 1, 1996·Anatomia, histologia, embryologia·C Salakij, T Watanabe
May 23, 2013·Pharmacology & Therapeutics·Stefan AmistenShanta J Persaud
Mar 27, 1990·European Journal of Pharmacology·E J VerspohlG Lambrecht
Apr 1, 1981·The Journal of Surgical Research·K R SirinekS Cataland
Feb 1, 1986·Journal of Endocrinological Investigation·V CoiroU Butturini
Feb 11, 1986·The American Journal of Physiology·B AhrénG J Taborsky
Jan 27, 2021·Biology·Rui GaoQuan Zhang
Jul 1, 1989·The American Journal of Physiology·N Rideau, J Simon
Dec 1, 1983·The American Journal of Physiology·J J HolstO V Nielsen
Apr 12, 2021·The Journal of Biological Chemistry·Tomozumi TakataniRohit N Kulkarni
Dec 1, 1995·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·F C BrunicardiD K Andersen

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