PMID: 8608006Apr 1, 1996Paper

Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme

Neuron
N C InestrosaJ Garrido

Abstract

Acetylcholinesterase (AChE), an important component of cholinergic synapses, colocalizes with amyloid-beta peptide (A beta) deposits of Alzheimer's brain. We report here that bovine brain AChE, as well as the human and mouse recombinant enzyme, accelerates amyloid formation from wild-type A beta and a mutant A beta peptide, which alone produces few amyloid-like fibrils. The action of AChE was independent of the subunit array of the enzyme, was not affected by edrophonium, an active site inhibitor, but it was affected by propidium, a peripheral anionic binding site ligand. Butyrylcholinesterase, an enzyme that lacks the peripheral site, did not affect amyloid formation. Furthermore, AChE is a potent amyloid-promoting factor when compared with other A beta-associated proteins. Thus, in addition to its role in cholinergic synapses, AChE may function by accelerating A beta formation and could play a role during amyloid deposition in Alzheimer's brain.

References

Oct 1, 1990·The Journal of Membrane Biology·N C Inestrosa, A Perelman
Jun 15, 1989·The Biochemical Journal·A Chatonnet, O Lockridge
Aug 1, 1989·Trends in Pharmacological Sciences·N C Inestrosa, A Perelman
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D A KirschnerD J Selkoe
Dec 15, 1986·Biochemical and Biophysical Research Communications·E M CastañoB Frangione
Jan 1, 1986·Neuroscience·M M Mesulam
Jul 14, 1971·Nature: New Biology·Z W Hall, R B Kelly
Apr 23, 1982·Science·R G StrubleD L Price
Mar 1, 1995·The Biochemical Journal·E M CastanoB Frangione
Oct 1, 1995·The Biochemical Journal·L L IversenM S Shearman
May 12, 1995·The Journal of Biological Chemistry·P N Deprez, N C Inestrosa
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·K C EvansP T Lansbury
Oct 1, 1994·Journal of Neurochemistry·C SotoN C Inestrosa
Jan 1, 1994·Annual Review of Pharmacology and Toxicology·P Taylor, Z Radić
Jan 1, 1994·Annual Review of Neuroscience·D J Selkoe
Sep 1, 1993·General Pharmacology·E Brandan, N C Inestrosa

❮ Previous
Next ❯

Citations

Jul 15, 1997·Journal of Neuroscience Research·C HolmesS A Greenfield
Oct 13, 1999·Journal of Neuroscience Research·M P MarzoloN C Inestrosa
Feb 4, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lynnette J CookDavid C Rubinsztein
Oct 23, 2002·Journal of Neuroscience Research·Cheol Hyoung ParkYoo-Hun Suh
Mar 29, 2000·Biochemical and Biophysical Research Communications·O F Olesen, L Dagø
Mar 11, 1998·Molecular and Chemical Neuropathology·C Opazo, N C Inestrosa
Oct 11, 2005·Archives of Pharmacal Research·Hong Nga NguyenJin Tae Hong
Jan 11, 2005·Neurotoxicity Research·Tomás PalomoRichard M Kostrzewa
Jun 22, 2006·Neurotoxicity Research·A Nordberg
Jan 30, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Osama SabriPeter Brust
Mar 11, 2005·Pediatric Surgery International·S W Moore, G Johnson
Oct 14, 2006·Journal of Neural Transmission·R Schliebs, T Arendt
Dec 17, 2009·Amino Acids·Anna MinariniCarlo Melchiorre
Jul 28, 2007·Cellular and Molecular Neurobiology·Hai Yan ZhangXi Can Tang
Sep 6, 2007·Cellular and Molecular Neurobiology·Zhi Fei WangDong Lu Bai
Aug 28, 2009·Journal of Molecular Neuroscience : MN·Ari MeersonDaniela Kaufer
Sep 6, 2008·Molecular Neurobiology·Daniela L RebolledoNibaldo C Inestrosa
Mar 29, 2013·Bioorganic & Medicinal Chemistry·Todd J EckroatSylvie Garneau-Tsodikova
Jun 24, 2008·Chemico-biological Interactions·S AkasofuH Ogura
May 10, 2005·Il Farmaco·Maria Laura BolognesiCarlo Melchiorre
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Maria Laura BolognesiCarlo Melchiorre
May 11, 2005·Pharmacology, Biochemistry, and Behavior·Amitava DasChandishwar Nath
Apr 1, 2003·Current Therapeutic Research, Clinical and Experimental·George T Grossberg
Oct 16, 2002·Journal of Immunological Methods·Glynis Johnson, Samuel W Moore
Oct 29, 1998·Toxicon : Official Journal of the International Society on Toxinology·P MarchotP Taylor
Oct 9, 2001·Mechanisms of Ageing and Development·V N Talesa
Sep 11, 2002·Molecular Immunology·Glynis Johnson, Samuel W Moore
May 26, 2001·Journal of Inorganic Biochemistry·C Exley, O V Korchazhkina
Jan 11, 2001·Pharmacology & Therapeutics·K Yamada, T Nabeshima
Sep 1, 2000·Brain Research. Brain Research Reviews·G V De Ferrari, N C Inestrosa
May 3, 2002·Neuroscience Research·Lei YangXue-Jun Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.