Acetylcholinesterase antagonist potentiated insulin action in fed but not fasted state

The Journal of Pharmacology and Experimental Therapeutics
Joshua SchaferW Wayne Lautt

Abstract

The glucose disposal effect of insulin is doubled in response to a meal. This meal-induced insulin sensitization results from insulin acting on the liver, in the presence of a permissive hepatic parasympathetic feeding signal and elevated hepatic glutathione (GSH), to release hepatic insulin-sensitizing substance (HISS), a hormone that acts selectively on skeletal muscle to stimulate insulin-mediated glucose uptake. Blockade of the parasympathetic feeding signal to the liver, either through surgical denervation or atropine-mediated antagonism of hepatic muscarinic receptors, eliminates the HISS response, resulting in HISS-dependent insulin resistance (HDIR) and decreasing the response to insulin by approximately 55% in the fed state. Insulin action in Sprague-Dawley rats, as determined with a rapidly sampled, transient euglycemic clamp in response to insulin (50 mU/kg), is decreased in a dose-dependent manner by atropine. In this study, we have used the ED75 atropine-induced model of HDIR. After a submaximal dose of atropine, potentiation of the remaining parasympathetic effect with the acetylcholinesterase antagonist neostigmine significantly restored postprandial insulin sensitization in a dose-dependent manner with peak effe...Continue Reading

References

Jan 1, 1977·The Journal of Nutrition·N TateishiH Shiozaki
Feb 1, 1993·Canadian Journal of Physiology and Pharmacology·H XieW W Lautt
Oct 1, 1995·Journal of Autonomic Pharmacology·H Xie, W W Lautt
May 18, 1999·Canadian Journal of Physiology and Pharmacology·W W LauttM P Macedo
Jun 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·W W LauttD J Legare
Dec 6, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Maria P GuarinoM Paula Macedo
Aug 28, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Maria P GuarinoM Paula Macedo
Mar 29, 2008·Metabolic Syndrome and Related Disorders·W Wayne Lautt
Jun 19, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rogério Tavares RibeiroMaria Paula Macedo
Dec 18, 2008·Canadian Journal of Physiology and Pharmacology·Rita S PatarrãoM Paula Macedo

❮ Previous
Next ❯

Citations

Oct 2, 2012·The British Journal of Nutrition·Kawshik K ChowdhuryW Wayne Lautt
Jun 15, 2012·Canadian Journal of Physiology and Pharmacology·Ana B FernandesM Paula Macedo
Mar 6, 2013·Canadian Journal of Physiology and Pharmacology·Kawshik K ChowdhuryW Wayne Lautt
Feb 3, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dick S DelbroStyrbjörn Friman
Oct 12, 2010·The American Journal of Medicine·Mehrul Hasnain, W Victor R Vieweg
May 7, 2015·PloS One·Ming ZhangEkaterina Rogaeva
Jun 30, 2021·Diabetes & Metabolic Syndrome·Sweta MohantySwati Swayamsiddha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
R T RibeiroM Paula Macedo
Canadian Journal of Physiology and Pharmacology
Rita S PatarrãoM Paula Macedo
© 2021 Meta ULC. All rights reserved