Acetylcholinesterase in cell adhesion, neurite growth and network formation

The FEBS Journal
Laura E Paraoanu, Paul G Layer

Abstract

The expression of acetylcholinesterase is not restricted to cholinergically innervated tissues and relates to both neurotransmission and multiple biological aspects, including neural development, stress response and neurodegenerative diseases. Therefore, the classical function of acetylcholinesterase has to be distinguished from its non-classical, e.g. enzymatic from non-enzymatic, functions. Here, the roles of acetylcholinesterase in cell adhesion, promoting neurite outgrowth and neural network formation are reviewed briefly, together with potential mechanisms to support these functions. Part of these functions may depend on the structural properties of acetylcholinesterase, for example, protein-protein interactions. Recent findings have revealed that laminin-1 is an interaction partner for acetylcholinesterase. The binding of acetylcholinesterase to this extracellular matrix component may allow cell-to-cell recognition, and also cell signalling via membrane receptors. Studies using monolayer and 3D spheroid retinal cultures, as well as the acetylcholinesterase-knockout mouse, have been instrumental in elaborating the non-classical functions of acetylcholinesterase.

References

Jan 1, 1992·Neuron·R J RivasD J Goldberg
Sep 1, 1990·Brain Research. Developmental Brain Research·F C Zhou
Jul 1, 1989·Trends in Neurosciences·S A Lipton, S B Kater
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P G Layer, O Sporns
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·H SoreqH Zakut
Jun 15, 1996·Journal of Cellular Biochemistry·R M Lafrenie, K M Yamada
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M GrifmanH Soreq
Dec 19, 1998·Journal of Neurobiology·C F Hohmann, J Berger-Sweeney
Dec 23, 1999·Matrix Biology : Journal of the International Society for Matrix Biology·M FalkP Ekblom
Apr 3, 2001·Nature Reviews. Neuroscience·H Soreq, S Seidman
Apr 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C Morgan, N C Inestrosa
Feb 20, 2002·Trends in Neurosciences·Paul G LayerElmar Willbold
Jul 11, 2002·Cell Death and Differentiation·X J ZhangY F Shi
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Klara R BirikhHermona Soreq
Aug 7, 2003·Trends in Genetics : TIG·Constance J Jeffery
Aug 30, 2003·Neuroscience and Biobehavioral Reviews·Christine F Hohmann
Oct 31, 2003·Trends in Neurosciences·Francisco G Scholl, Peter Scheiffele
Aug 27, 2004·The Protein Journal·Rathanam Boopathy, Paul G Layer
Dec 8, 2004·The European Journal of Neuroscience·Afrim H BytyqiPaul G Layer
May 24, 2005·Current Opinion in Pharmacology·Israel Silman, Joel L Sussman
Feb 28, 2007·Investigative Ophthalmology & Visual Science·Rinat KehatIdo Perlman
Jul 4, 2007·The Journal of Biological Chemistry·Susana Constantino Rosa SantosCarlota Saldanha

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Citations

Nov 22, 2013·Archives of Toxicology·Syed M NurulainAbdu Adem
Feb 22, 2013·Environmental Health Perspectives·Heidi Qunhui XieBin Zhao
Jan 31, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Miroslav Pohanka
Jan 8, 2016·Molecular Neurobiology·María-Salud García-AyllónJavier Sáez-Valero
Oct 19, 2016·Environmental Toxicology·Mohammad Hadi ZareiMasoumeh Fakhr Taha
Jul 24, 2013·Trends in Neurosciences·Jason D WarrenMartin N Rossor
Jan 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yves Bourne, Pascale Marchot
Nov 15, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Charalampos DokosGeorge Koliakos
Feb 25, 2010·The Journal of Obstetrics and Gynaecology Research·Sumire YamateHideo Nishigori
Sep 13, 2008·The FEBS Journal·Glynis JohnsonSamuel W Moore
Dec 7, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anuttama KulkarniKrishanu Ray
Jun 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jakub JończykBarbara Malawska
Jun 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qiyun WuKarl W K Tsim
Nov 11, 2009·Acta Biochimica Et Biophysica Sinica·Xiaowen GongXuejun Zhang
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Xiaohe LuoChunyi Wen
Feb 21, 2021·Osteoarthritis and Cartilage·Marianne LauwersChunyi Wen
Dec 12, 2020·Progress in Biophysics and Molecular Biology·Israel Silman

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