PMID: 2486098Jan 1, 1989Paper

Acetylcholinesterase in the cochlea on normal guinea pigs by light and electron microscopy

Zhonghua er bi yan hou ke za zhi
J Sun

Abstract

The distribution of AchE activity in the cochleae of 42 normal guinea pigs was studied with thiocholine Cu-ferrocyanide method. Light microscopy revealed the AchE activity in the following areas: 1. the inner spiral bundle, 2. the spiral tunnel bundle, 3. the upper tunnel radial fibers, and 4. the large nerve endings at the base of the outer hair cells. Activity of AchE was most abundant in the basal turn and decreased gradually towards the apex. There was also a decreasing AchE from the first to the third row of outer hair cells. In the fourth turn, AchE activity was demonstrated only in the large nerve endings under the first row of outer hair cells. Under electron microscopy, the reaction was found to be localized to the following structures: 1. the axolemma of the small efferent fibers and their presynaptic enlargements in the inner spiral bundle, 2. the outer surface of the upper tunnel radial fibers and the spiral tunnel bundle, and 3. the large efferent nerve endings in contact with the base of the outer hair cells.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.