Acetylcholinesterase inhibitors from Stephania venosa tuber

The Journal of Pharmacy and Pharmacology
Kornkanok IngkaninanNantaka Khorana

Abstract

Acetylcholinesterase (AChE) inhibitors have lately gained interest as potential drugs in the treatment of Alzheimer's disease. Three AChE inhibitors were isolated from tubers of a Thai medicinal plant, Stephania venosa (Bl) Spreng. They were identified as quaternary protoberberine alkaloids, stepharanine, cyclanoline and N-methyl stepholidine. They expressed inhibitory activity on AChE with IC50 values (concentration that caused 50% inhibition of activity) of 14.10 +/- 0.81, 9.23 +/- 3.47 and 31.30 +/- 3.67 microM, respectively. The AChE inhibitory activity of these compounds was compared with those of the related compounds, palmatine, jatrorrhizine and berberine, as well as tertiary protoberberine alkaloids isolated from the same plant, stepholidine and corydalmine. The results suggest that the positive charge at the nitrogen of the tetrahydroisoquinoline portion, steric substitution at the nitrogen, planarity of the molecule or substitutions at C-2, -3, -9, and -10 affect the AChE inhibitory activity of protoberberine alkaloids.

References

Jun 1, 1983·Planta medica·J UlrichováV Simánek
Mar 22, 2000·Chemical & Pharmaceutical Bulletin·T TanahashiH Nayeshiro
Jul 5, 2003·Phytochemistry·Joanne T BlanchfieldWilliam Kitching
Aug 28, 2003·Lancet Neurology·Elio ScarpiniHoward Feldman
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Mar 18, 2004·The Journal of Pharmacy and Pharmacology·Clive MillsJohn J Walsh
Apr 15, 2004·Phytochemistry·Yumi NishiyamaFrancis D Juma

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Citations

Aug 5, 2009·Biological & Pharmaceutical Bulletin·Hyun Ah JungJae Sue Choi
Sep 15, 2009·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Jian-ye YuanDa-zheng Wu
Oct 12, 2013·Molecular Neurobiology·Hamid Kalalian MoghaddamFatemeh Mahboobi
Jun 4, 2014·International Journal of Molecular Sciences·Miroslav Pohanka
Sep 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ling-Ling YuZhong-Mei Zou
May 21, 2011·European Journal of Pharmacology·JianYe YuanDaZheng Wu
Aug 31, 2010·Journal of Ethnopharmacology·Deepak Kumar SemwalUsha Rawat
Jul 1, 2008·European Journal of Pharmacology·Shrinivas K Kulkarni, Ashish Dhir
Feb 2, 2008·The Journal of Pharmacy and Pharmacology·María Elena Sánchez-MendozaAndrés Navarrete
Feb 9, 2012·The Journal of Pharmacy and Pharmacology·Beibei ZhangDazheng Wu
Nov 19, 2013·The Journal of Pharmacy and Pharmacology·Eduardo Luis KonrathAmélia T Henriques
Dec 10, 2009·Phytotherapy Research : PTR·S K Kulkarni, Ashish Dhir
Sep 5, 2014·Natural Product Research·Deepak Kumar Semwal, Ruchi Badoni Semwal
Nov 12, 2017·Natural Product Research·Manju BalaBikram Singh
Mar 8, 2012·Toxicology Mechanisms and Methods·Sarawoot GomuttapongSuchinda Malaivijitnond
Jun 2, 2020·Pharmaceutical Biology·Natthinee AnantachokeNarong Nuntasaen
Jan 7, 2020·Mini Reviews in Medicinal Chemistry·Hulya Akıncıoğlu, İlhami Gülçin
Apr 28, 2020·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Yueping JiangShao Liu
Jul 28, 2018·BioMed Research International·Xin-Chen WangShi-Jian Quan
Sep 15, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Taiwo Olayemi ElufioyeSolomon Habtemariam
Feb 20, 2020·Current Medicinal Chemistry·Natália Martins, Isabel C F R Ferreira

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