PMID: 6970979Jan 1, 1980Paper

Acetylsalicylic acid-induced gastrointestinal bleeding determined by a 51Cr method on a day-to-day basis

Scandinavian Journal of Gastroenterology
J H DybdahlL Aanstad

Abstract

The daily gastrointestinal blood loss caused by plain and microencapsulated acetylsalicylic acid (ASA) tablets was compared. Fourteen healthy, male volunteers participated in a double-blind, cross-over study, lasting 38 days. Before drug administration a median gastrointestinal bleeding of 0.9 ml/24 h was observed. During oral intake of 1.5 g ASA twice a day for 5 days, an increased faecal blood loss was seen in all volunteers. The increase was significant for both plain and microencapsulated ASA (p less than 0.01). Plain ASA tablets, however, caused a greater faecal blood loss than the microencapsulated tablets (p = 0.05), maximum median levels being 6.2 ml/24 h and 3.9 ml/24 h, respectively. An optimal design of radiochromium studies for determination of drug-induced gastrointestinal blood loss is discussed.

References

Dec 28, 1979·Deutsche medizinische Wochenschrift·P MüllerB Simon
Aug 1, 1979·Clinical Pharmacology and Therapeutics·B M Rothschild
Sep 1, 1979·Clinical Pharmacology and Therapeutics·M OsnesE Thom
Dec 1, 1975·Australasian Radiology·I M Kendall-Smith
Jan 1, 1976·Drugs·A R Cooke
Jul 1, 1969·Clinical Pharmacology and Therapeutics·J R Leonards, G Levy
Oct 1, 1970·Journal of Pharmaceutical Sciences·J R Leonards, G Levy
Jul 12, 1965·JAMA : the Journal of the American Medical Association·J R LEONARDS, G LEVY

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Citations

Feb 1, 1983·Digestive Diseases and Sciences·J N HuntC L Jiang
Jan 1, 1985·Journal of Chronic Diseases·M C BelconP Tugwell
Jun 1, 1987·Scandinavian Journal of Gastroenterology·A Malchow-Møller, P J Ranløv
Jan 1, 1981·Scandinavian Journal of Gastroenterology·J H DybdahlS Larsen
Mar 1, 1987·Medical Toxicology·O Brors

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