PMID: 7008184Jan 1, 1981Paper

Acetylsalicylic acid-induced prolongation of bleeding time in healthy men

Scandinavian Journal of Haematology
J H DybdahlS Larsen

Abstract

Bleeding times were determined in 25 healthy men using the Thrombolette bleeding time device. The median bleeding times prior to low and high doses of acetylsalicylic acid (ASA), 245 and 230 s, were not significantly different (P = 0.12). 2 h after randomized ingestion of 0.44 and 3.96 g ASA, the median bleeding times rose to 450 and 430 s, respectively. Both increased in bleeding time were significant (P less than 0.001), but the difference was not significant (P = 0.29). The maximum increase in bleeding time was estimated to occur 2.6 h after ingestion of a single low ASA dose, and 2.4 h after a single high dose. Following ingestion of 0.44 as well as 3.96 g ASA the bleeding time returned to basal levels within 5-6 d. Compared to the younger ones, volunteers with a higher age showed a tendency to have lower plasma salicylate levels as well as smaller increases in bleeding times following ASA ingestion.

References

Oct 7, 1978·Lancet·J O'Grady, S Moncada
Nov 18, 1978·Lancet·S M RajahR Kester
Jun 9, 1979·Lancet·H C GodalS Larsen
Jul 28, 1979·Lancet·A GirolamiM L Randi
Oct 1, 1978·American Journal of Clinical Pathology·R KumarD Deykin
Aug 1, 1979·Clinical Pharmacology and Therapeutics·B M Rothschild
Sep 1, 1968·The Journal of Clinical Investigation·H J WeissS Kochwa

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Citations

Mar 1, 1996·Journal of Clinical Gastroenterology·J P DayB I Hirschowitz
May 25, 2006·Annals of the Royal College of Surgeons of England·Mohamed Khalid EnverFrank I Chinegwundoh
Oct 16, 1982·The Medical Journal of Australia·R I Baker, W R Pitney

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