Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis

PloS One
Meiling SuBanghao Zhu

Abstract

Various drugs have been developed to treat obesity, but these have undesirable secondary effects, and an efficient but non-toxic anti-obesity drug from natural sources is desired. This study investigated the anti-obesity effects and mechanisms of action of acetylshikonin (AS)-which is used in traditional Chinese medicine-in rats on a high-fat diet (HFD). Rats were fed a normal diet or an HFD; the latter group was received no treatment or were treated with 100, 300, or 900 mg/kg AS extract by intragastric administration for 6 weeks. In addition, 3T3-L1 adipocytes were treated with AS and the effects on adipogenesis and lipolysis were evaluated by western blot analysis of adipogenic transcription factors and lipid-metabolizing enzyme levels and the phosphorylation status of protein kinase (PK) A and hormone-sensitive lipase (HSL). AS prevented HFD-induced obesity including reduction in body weight, white adipose tissue content, liver mass, and serum triglyceride and free fatty acid levels in rats. It also suppressed the expression of adipogenic differentiation transcription factors and decreased the expression of the adipocyte-specific proteins HSL and adipose triglyceride lipase (ATGL). Furthermore, AS treatment induced lipolysi...Continue Reading

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Citations

Aug 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei-Ling SuBang-Hao Zhu
Jun 7, 2016·Biochemical and Biophysical Research Communications·Yu HeBanghao Zhu
Sep 22, 2020·Pharmaceutical Biology·Zhiqin ZhangJian Ni
Jan 27, 2019·The Journal of International Medical Research·Weijia YangTao Wang
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Yanfei LiuRui Gao
Oct 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fangfang XuXinmiao Liang
Jan 29, 2021·International Journal of Molecular Sciences·Dexter L PuckettAhmed Bettaieb
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monika BhardwajSudhir Kumar Kataria

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Methods Mentioned

BETA
light microscopy
Assay
electrophoresis

Software Mentioned

GraphPad
Graph Pad Prism

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