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Acetylshikonin induces apoptosis of human leukemia cell line K562 by inducing S phase cell cycle arrest, modulating ROS accumulation, depleting Bcr-Abl and blocking NF-κB signaling

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie

Dec 7, 2019

Gangping HaoZhongfa Yang

Abstract

Acetylshikonin, a natural naphthoquinone derivative compound from Lithospermum erythrorhyzon, has been reported to kill bacteria, suppress inflammation, and inhibit tumor growth. However, the effect of acetylshikonin on human chronic myelocytic leukemia (CML) cells apoptosis and its det...read more

Mentioned in this Paper

Caspase-9
Study
Cyclophosphamide
Annexin A5
Cleaved
Caspase-3
PARP1 protein, human
DDAH2
Cell Proliferation
NFKB Signaling Pathway
2
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Acetylshikonin induces apoptosis of human leukemia cell line K562 by inducing S phase cell cycle arrest, modulating ROS accumulation, depleting Bcr-Abl and blocking NF-κB signaling

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie

Dec 7, 2019

Gangping HaoZhongfa Yang

PMID: 31810012

DOI: 10.1016/j.biopha.2019.109677

Abstract

Acetylshikonin, a natural naphthoquinone derivative compound from Lithospermum erythrorhyzon, has been reported to kill bacteria, suppress inflammation, and inhibit tumor growth. However, the effect of acetylshikonin on human chronic myelocytic leukemia (CML) cells apoptosis and its det...read more

Mentioned in this Paper

Caspase-9
Study
Cyclophosphamide
Annexin A5
Cleaved
Caspase-3
PARP1 protein, human
DDAH2
Cell Proliferation
NFKB Signaling Pathway
2

Related Papers

Paper Details
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    References currently unavailable

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