Achalasia: a vagal disease

Scandinavian Journal of Gastroenterology
Bodil OhlssonG Sundkvist

Abstract

Achalasia is considered to be a primary motor disorder of the oesophagus. However, there is increasing evidence to suggest extra-oesophageal involvement in this disease. Vagal disturbances at different levels and extra-oesophageal dysmotility have been reported in several studies. The aim of this study was to examine cardiovascular reflexes in patients with achalasia further to evaluate the involvement of the autonomic nervous system outside the oesophagus in this entity. Five patients (age range 38-58 years, median 45 years) diagnosed with achalasia were assessed for the autonomic nerve function by the heart rate reaction to deep breathing (E/I ratio) and to tilt (acceleration and brake index). The blood pressure reaction to tilt was also assessed. The results were compared with a control group comprising 56 healthy individuals (age range 16-59 years, median 40 years). Patients with achalasia had a significantly decreased E/I ratio compared with controls (absolute values 1.13 (0.23) (median value (interquartile range)) versus 1.38 (0.14): P=0.0309, age corrected values -1.39 (1.49) versus -0.25 (1.20): P=0.0457). This reflects impairment of the vagus nerve. In contrast, sympathetic nerves were not affected, as the acceleration...Continue Reading

References

Aug 1, 1991·Digestive Diseases and Sciences·V AnneseT Federici
Apr 1, 1986·Gastroenterology·R H HollowayR C Arndorfer
Jul 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·P M SatchellA H Goodman
Mar 1, 1995·Gut·F MearinJ R Malagelada
Mar 1, 1993·Gut·A E BharuchaA R Zinsmeister
Jan 1, 1997·Digestive Diseases·S Birgisson, J E Richter
Aug 5, 2000·Journal of Diabetes and Its Complications·O May, H Arildsen
Jun 6, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·A GottsäterG Sundkvist
Sep 1, 1964·Annals of Surgery·R R CASSELLAF H ELLIS

❮ Previous
Next ❯

Citations

Jul 21, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B HerrerosA Benages
May 23, 2015·BioMed Research International·Marco ArdesiaWalter Fries
Jun 6, 2015·Journal of Crohn's & Colitis·Tibor HlavatyJuraj Payer
May 20, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S-Y ParkK Monahan
Jan 23, 2008·Journal of Clinical Gastroenterology·Tomas MattssonBodil Ohlsson
Aug 29, 2006·World Journal of Gastroenterology : WJG·Seng-Kee ChuahChuan-Mo Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Annals of the Rheumatic Diseases
P S KlimiukM I Jayson
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
B HerrerosA Benages
Journal of Clinical Gastroenterology
Hakan AlagozluMeltem Ergun
© 2022 Meta ULC. All rights reserved