Achalasia Patients Are at Nutritional Risk Regardless of Presenting Weight Category

Digestive Diseases and Sciences
Carolyn NewberryKristle L Lynch

Abstract

Achalasia is an esophageal motor disorder that leads to swallowing dysfunction and weight loss. Nutritional risk in achalasia patients is not well defined. The aims of this study were to define baseline body mass index (BMI), changes in weight, and nutritional risk over time in a large cohort of achalasia patients. This was a retrospective cohort study of achalasia patients at a tertiary care center with documented BMI, symptom severity as per Eckardt score, and nutritional risk assessment as per the Malnutrition Universal Screening Tool, which considers BMI, degree of recent weight loss, and acuity of disease. Among the 337 patients presenting for achalasia management, 179 had confirmed disease. Upon presentation 69.8% of patients were classified as overweight or obese. Using the Malnutrition Universal Screening Tool, we found 50% of patients to be at moderate or high risk for malnutrition at presentation. Eckardt score (OR 1.15, 95% CI 1.05-1.26), duration of disease (OR for each additional month 1.04, 95% CI 1.01-1.08), and female gender (OR 1.76, 95% CI 1.02-3.03) were independent predictors of increased risk for malnutrition. Nutrition risk score decreased after therapy in 93.3% of patients. Despite a high prevalence of ov...Continue Reading

References

Dec 6, 2006·Surgical Endoscopy·S S RakitaA Rosemurgy
Jun 26, 2008·World Journal of Surgery·Piero M FisichellaMarco G Patti
Sep 29, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael HulselmansJan Tack
Apr 28, 2011·Nature Reviews. Gastroenterology & Hepatology·Alexander J Eckardt, Volker F Eckardt
Feb 22, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J BredenoordUNKNOWN International High Resolution Manometry Working Group
Jul 24, 2013·The American Journal of Gastroenterology·Michael F VaeziMarcelo F Vela
Dec 4, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P J KahrilasUNKNOWN International High Resolution Manometry Working Group
Apr 12, 2016·Journal of Gastroenterology and Hepatology·Nishmi GunasingamPayal Saxena
Jun 9, 2016·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
Mar 30, 2017·Journal of Neurogastroenterology and Motility·Han Ho JeonJeffrey L Conklin

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Citations

Jun 17, 2020·European Journal of Gastroenterology & Hepatology·Pamela MilitoLuigi Bonavina
Jun 20, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Andric C Perez-OrtizGonzalo Torres-Villalobos
Jan 3, 2021·Digestive Diseases and Sciences·Kamesh GuptaDavid Desilets

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