Achalasia: physiology and etiopathogenesis

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
R E Kraichely, G Farrugia

Abstract

Achalasia is a disorder of esophageal motility that has been well documented for over 300 years. Despite this, the initiating factor or factors and the underlying mechanisms leading to the characteristic features of achalasia, the absence of distal esophageal peristalsis and abnormal lower esophageal sphincter relaxation, are still not well understood. Recent work has shed light on changes in neurotransmission and cell signaling in the lower esophagus and lower esophageal sphincter that lead to achalasia. A number of recent reviews have thoroughly discussed diagnostic and therapeutic modalities and the reader is referred to these for in-depth review of these topics. The focus of this review will be on our current understanding of the physiology of esophageal peristalsis and lower esophageal sphincter function as it relates to achalasia and on available evidence for etiology and proposed pathophysiologic mechanisms.

References

Oct 1, 1978·Australian and New Zealand Journal of Medicine·J A CuthbertJ R Turtle
Jul 1, 1992·Gastroenterology·S YamatoR K Goyal
Oct 1, 1991·Journal of Clinical Gastroenterology·W G PatersonL R Da Costa
Oct 1, 1991·Canadian Journal of Physiology and Pharmacology·F ChristinckE E Daniel
Nov 26, 1991·Regulatory Peptides·R UddmanF Sundler
Apr 1, 1989·Gut·J F Mayberry, M Atkinson
Mar 1, 1989·Digestive Diseases and Sciences·R K WongJ R Baker
Jan 1, 1988·Gut·J F Mayberry, M J Mayell
Apr 1, 1986·Gastroenterology·R H HollowayR C Arndorfer
Apr 1, 1986·Gastroenterology·P O KatzD O Castell
Mar 1, 1966·American Journal of Surgery·J S Pierandozzi, J H Ritter
Oct 1, 1967·Diseases of the Chest·D R SandersonA M Olsen
Jan 1, 1984·European Neurology·F GemignaniE Govoni
Oct 1, 1983·Journal of the Autonomic Nervous System·O Lundgren
Aug 1, 1983·Digestive Diseases and Sciences·D J Costigan, R E Clouse
Jul 1, 1982·Digestive Diseases and Sciences·D T Stein, C M Knauer
Nov 1, 1993·European Journal of Clinical Investigation·F MearinJ R Malagelada
Sep 1, 1995·Digestive Diseases and Sciences·T J Duntemann, D M Dresner
Mar 1, 1995·Gut·F MearinJ R Malagelada
Sep 1, 1994·Journal of Clinical Gastroenterology·H G PreiksaitisN E Diamant
Nov 1, 1996·Canadian Journal of Physiology and Pharmacology·S XueN E Diamant
Feb 1, 1997·Digestive Diseases and Sciences·S BirgissonJ E Richter
Jan 20, 1998·Journal of Pediatric Surgery·J L KellyW O Kirwan
Sep 9, 1998·The American Journal of Physiology·P T SzymanskiR K Goyal
Dec 22, 1998·The American Journal of Gastroenterology·T PodasJ Mayberry
Jun 11, 1999·The American Journal of Gastroenterology·N ZárateJ R Malagelada
Jun 26, 1999·Gastroenterology·G N VerneW C Wu
Mar 11, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·F Mearin, J R Malagelada
Aug 10, 2000·The American Journal of Surgical Pathology·S B ClarkJ R Goldblum
Sep 21, 2000·The New England Journal of Medicine·S VerninoV A Lennon
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·Y ZhangW G Paterson
Dec 29, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S KapurA Marette

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Citations

Jun 6, 2009·Digestive Diseases and Sciences·Robert E KraichelyVanda A Lennon
Sep 18, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Garrett R RollGuilherme M Campos
Sep 1, 2008·Journal of Crohn's & Colitis·Itay MazaRami Eliakim
Oct 8, 2008·Trends in Immunology·Silvio Danese
Dec 25, 2008·Annals of Surgery·Guilherme M CamposRuxandra Ciovica
Oct 11, 2012·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Jihui LiRaul J Rosenthal
Apr 14, 2012·Journal of Gastroenterology and Hepatology·Lani PrideauxSiew C Ng
Feb 19, 2010·BMC Gastroenterology·Marilanda F BelliniMarileila Varella-Garcia
Jun 23, 2011·Clinical and Experimental Gastroenterology·Luca DugheraFabio Cisarò
Oct 18, 2011·Internal Medicine·Shin'ichi MiyamotoTsutomu Chiba
Jul 9, 2010·World Journal of Gastroenterology : WJG·Randa-M MostafaHosam Hamdy
Feb 13, 2014·International Journal of Molecular Sciences·Marilia da S Nascimento SantosEdda Lisboa Leite
Aug 25, 2012·Journal of Biomedicine & Biotechnology·Marilanda Ferreira BelliniAna Elizabete Silva
Apr 1, 2010·Clinical Journal of Gastroenterology·Hugh J McMillan, Jayashri Srinivasan
Sep 13, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J WangY Cui
Jan 20, 2009·Current Problems in Surgery·Thomas J WatsonVirginia R Litle
May 24, 2008·Gastroenterology Clinics of North America·Purna Kashyap, Gianrico Farrugia
Apr 29, 2008·Human Pathology·Simone Wanderley PinheiroSheila Jorge Adad
Jan 29, 2008·The Annals of Thoracic Surgery·Virginia R Litle
Mar 25, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F PaladiniR Sorrentino
Nov 21, 2008·Journal of Forensic Sciences·Sarah SchalinskiRoger W Byard
Apr 16, 2008·Alimentary Pharmacology & Therapeutics·G Di NardoR De Giorgio
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G Farrugia
Apr 12, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-M LinX-Z Shi
Feb 9, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M HoshinoK Yanaga
Apr 7, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A R de LeónA G Vigo
May 16, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B LiesA Friebe
Apr 28, 2010·The Laryngoscope·Peter C BelafskyRebecca J Leonard
Oct 2, 2015·Journal of Neurogastroenterology and Motility·Yoon Suh DoHye Kyung Lee
Jul 6, 2015·Current Gastroenterology Reports·Shamaila H WaseemJoseph M Croffie
Jan 19, 2013·Arquivos brasileiros de endocrinologia e metabologia·Ana Rosa P QuiduteJosé Walter Correia
Aug 5, 2016·Physiology·Kenton M SandersSean M Ward
Oct 17, 2009·Journal of Clinical Gastroenterology·Vincenzo VillanacciGabrio Bassotti
Apr 25, 2012·Journal of Tropical Medicine·Marilanda Ferreira BelliniAna Elizabete Silva

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