Abstract
Alzheimer's disease (AD) is the most common form of dementia in elder people, characterised by a progressive decline in memory as a result of an impairment of cholinergic neurotransmission. To date acetylcholinesterase inhibitors (AChEIs) have become the most prescribed drugs for the symptomatic treatment of mild to moderate AD. However, the traditional "one molecule-one target" paradigm is not sufficient and appropriate to yield the desired therapeutic efficacy since multiple factors, such as amyloid-β (Aβ) deposits, neuroinflammation, oxidative stress, and decreased levels of acetylcholine (ACh) have been thought to play significant roles in the AD pathogenesis. New generation of multi-target drugs is earnestly demanded not only for ameliorating symptoms but also for modifying the disease. Herein, we delineated the catalytic and non-catalytic functions of AChE, and summarized the works of our group and others in research and development of novel AChEI-based multi-target-directed ligands (MTDLs), such as dual binding site AChEIs and multitarget AChEIs inhibiting Aβ aggregation, regulating Aβ procession, antagonizing platelet-activating factor (PAF) receptor, scavenging oxygen radical, chelating metal ions, inhibiting monoamine...Continue Reading
Citations
Feb 7, 2019·Frontiers in Aging Neuroscience·Yu WangHao Wang
Aug 29, 2017·Chemistry : a European Journal·Amandine Conte-DabanChristelle Hureau
Apr 19, 2019·Journal of Medical Virology·Qingsong Qin, Yun Li
May 16, 2019·Scientific Reports·Mariana G FronzaLucielli Savegnago
Dec 15, 2016·Expert Opinion on Therapeutic Patents·Stanton F McHardyMatthew C Valdez
Nov 24, 2017·Metallomics : Integrated Biometal Science·Nilda V BarbosaJoão B T Rocha
May 10, 2018·ChemMedChem·Deepti GoyalBhupesh Goyal
Jul 1, 2020·Fundamental & Clinical Pharmacology·Adel A GomaaMariam A Nicola
Dec 28, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Yao ChenHaopeng Sun
Jul 21, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Nikolay T Tzvetkov, Liudmil Antonov
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sofia BenfeitoFernanda Borges
Mar 17, 2020·Natural Product Research·Andressa Domingos PolliJoão Lúcio Azevedo
Sep 22, 2018·Translational Neurodegeneration·Yuhuan ShiHao Wang
Oct 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lucie CahlíkováLubomír Opletal
Jan 3, 2020·Current Medicinal Chemistry·Ting YangHailin Cong
Sep 6, 2020·Bioorganic Chemistry·Golaleh GhotbiSiavoush Dastmalchi
Sep 27, 2019·Phytochemistry·Erika PlazasLuis Enrique Cuca
Nov 24, 2019·The Journal of Nutritional Biochemistry·Gagandeep Kaur, Atish Prakash
May 10, 2020·Bioorganic & Medicinal Chemistry Letters·Lee J Macklin, Jason P Schwans
Feb 12, 2021·Bioorganic Chemistry·Pritam ThapaMukut Sharma
Mar 11, 2020·Bioorganic Chemistry·Erika PlazasLuis Enrique Cuca
Mar 11, 2021·Bioorganic Chemistry·Shahin AbdpourMehdi Khoobi
Jul 15, 2021·Pathology Oncology Research : POR·Yanzhi BiYang Ling
May 22, 2020·ACS Medicinal Chemistry Letters·Marco CattoCosimo Damiano Altomare
Aug 11, 2018·Chemical Reviews·Masha G SavelieffMi Hee Lim
Dec 7, 2018·ACS Chemical Neuroscience·Huan Wang, Haiyan Zhang
Oct 2, 2020·ACS Chemical Neuroscience·Yaojun JuKin Yip Tam
Jul 17, 2019·ACS Chemical Neuroscience·Dushyant V PatelMange Ram Yadav