Achievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe: The International ChoLesterol management Practice Study (ICLPS)

European Journal of Preventive Cardiology
Nicolas DanchinICLPS Investigators

Abstract

Background Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable lipid-lowering therapy (LLT) in countries outside Western Europe. Methods This cross-sectional observational study was conducted in 452 centres (August 2015-August 2016) in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America. Patients ( n = 9049) treated for ≥3 months with any LLT and in whom an LDL-C measurement on stable LLT was available within the previous 12 months were included. Results The mean±SD age was 60.2 ± 11.7 years, 55.0% of patients were men and the mean ± SD LDL-C value on LLT was 2.6 ± 1.3 mmol/L (101.0 ± 49.2 mg/dL). At enrolment, 97.9% of patients were receiving a statin (25.3% on high intensity treatment). Only 32.1% of the very high risk patients versus 51.9% of the high risk and 55.7% of the moderate risk patients achieved their LDL-C goals. On multivariable analysis, factors independently associated with not achieving LDL-C goals were no (versus lower dose) statin therapy, a higher (versus lower) dose of statin, statin intolerance, overweight and obesity, female sex, neurocognitive disorders, level of cardiovascular risk, L...Continue Reading

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Citations

Apr 26, 2018·European Journal of Preventive Cardiology·Guy G De Backer
Nov 15, 2018·European Journal of Preventive Cardiology·Barak ZafrirErez Sharoni
Jan 9, 2019·Journal of Cellular Physiology·Maryam PasebanAmirhossein Sahebkar
Apr 17, 2019·Heart·Márcio S Bittencourt, Fernando H Y Cesena
Dec 29, 2019·European Journal of Heart Failure·Markus S AnkerStefan D Anker
Jul 1, 2020·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Helen J CurtisBen Goldacre
Jul 31, 2020·Expert Opinion on Drug Metabolism & Toxicology·Jian-Jun LiStephen J Nicholls
Oct 24, 2019·European Journal of Preventive Cardiology·Ana Abreu
Aug 11, 2020·Expert Opinion on Pharmacotherapy·Brian TomlinsonChristopher Wai Kei Lam
Feb 26, 2019·European Journal of Preventive Cardiology·Massimo F Piepoli
Jul 31, 2019·European Journal of Preventive Cardiology·Iryna DykunAmir A Mahabadi
May 6, 2019·European Journal of Preventive Cardiology·Guy G De Backer
Mar 19, 2019·European Journal of Preventive Cardiology·Massimo F Piepoli
Oct 28, 2019·International Journal of Environmental Research and Public Health·Kenny Mendoza-HerreraSimón Barquera
Apr 10, 2020·European Journal of Preventive Cardiology·Massimo F Piepoli
Feb 14, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Frederick J RaalDirk J Blom
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Sep 30, 2021·Cardiology and Therapy·Konstantinos TsioufisJoris van Vugt

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

DYSIS
IT
TAP
IMPROVE

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