Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies

Pediatric Diabetes
Petter BjornstadKristen J Nadeau

Abstract

Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index (BMI). We hypothesized that ISPAD/ADA goal achievement would be associated with better insulin sensitivity (IS) and cardiopulmonary fitness. IS was quantified as glucose infusion rate (GIR) from a hyperinsulinemic-euglycemic clamp in youth with type 1 diabetes from the RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) (n = 86) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) (n = 41) cohorts (n = 127; age 15.7 ± 2.2 years, 52% girls). Cardiopulmonary fitness was measured as peak oxygen consumption (VO2 peak/kg) during upright (RESISTANT) or supine (EMERALD) cycle ergometry and were stratified by cycle type. Goal achievement was defined as HbA1c < 7.5%, BP < 90th percentile, LDL-cholesterol < 100 mg/dL, HDL-cholesterol > 35 mg/dL, triglycerides < 150 mg/dL and BMI < 85th percentile. Participants were stratified into 3 groups: achieving 0-3 goals (n = 52), 4 goals (n = 48), and 5-6 goals (n = 27). Differences between groups were ex...Continue Reading

References

Oct 14, 2004·The Journal of Pediatrics·Jody S KrantzFrancine R Kaufman
Dec 24, 2004·Diabetes Care·Janet SilversteinUNKNOWN American Diabetes Association
Jan 16, 2008·Diabetologia·H D MargeirsdottirUNKNOWN Norwegian Study Group for Childhood Diabetes
Jan 31, 2008·American Journal of Epidemiology·B RosnerB Falkner
Jul 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Kristen J NadeauJudith G Regensteiner
Nov 17, 2009·The Journal of Clinical Endocrinology and Metabolism·Kristen J NadeauJane E B Reusch
Aug 13, 2011·Journal of Applied Physiology·Frank W BoothMichael D Roberts
Feb 19, 2013·Diabetes Care·Sarah Stark CasagrandeCatherine C Cowie
Jun 26, 2013·The New England Journal of Medicine·Rena R WingSusan Z Yanovski
Oct 10, 2013·Scandinavian Journal of Medicine & Science in Sports·W MitranunD Suksom
Oct 25, 2013·The Journal of Clinical Endocrinology and Metabolism·Sarah K LyonsMark A Sperling
Dec 20, 2013·Pediatric Diabetes·Sarah K LyonsVicki S Helgeson
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jan 28, 2014·Journal of Diabetes and Its Complications·Petter BjornstadDavid M Maahs
May 7, 2014·Current Diabetes Reports·Petter Bjornstad, R Paul Wadwa
Jun 27, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·H QuirkC Glazebrook
Aug 30, 2014·Circulation·David M MaahsUNKNOWN American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Dis
Sep 4, 2014·Pediatric Diabetes·Carlo AceriniRagnar Hanas
Oct 11, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·P BjornstadJ K Snell-Bergeon
Feb 17, 2015·World Journal of Diabetes·Petter BjornstadDavid M Maahs
Aug 10, 2016·Pediatric Diabetes·Christine L ChanKristen J Nadeau

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Citations

Jun 11, 2020·Current Opinion in Pediatrics·Elżbieta Niechciał, M Loredana Marcovecchio
Dec 31, 2020·Journal of Diabetes Investigation·Bartłomiej MatejkoMaciej T Malecki

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