journal cover

Achieving large dynamic range control of gene expression with a compact RNA transcription-translation regulator

Nucleic Acids Research

Apr 8, 2017

Alexandra M Westbrook, Julius B Lucks

Abstract

RNA transcriptional regulators are emerging as versatile components for genetic network construction. However, these regulators suffer from incomplete repression in their OFF state, making their dynamic range less than that of their protein counterparts. This incomplete repression cause...read more

Mentioned in this Paper

In Vivo
Ridges-off-the-end Syndrome
Transcriptional Regulation
Primary RNA Transcript
Regulation of Biological Process
Transcription Termination
Transcription, Genetic
Antisense RNA
Protein Biosynthesis
Gene Expression
23
40
Paper Details
References
  • References37
  • Citations5
1234
  • References37
  • Citations5
1

Similar Papers Found In These Feeds

Epigenome Engineering

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of dna methylation. Discover the latest research here.

HDR in Genome Engineering

Homology-directed repair (HDR) is a double-strand break repair pathway that can be exploited to modify genomes in many organisms. Researchers are now using the CRISPR-Cas system to control the specificity of HDR genome engineering techniques. Here is the latest research.

Non-coding Variants in Cancer

Mutations, single nucleotide variants and large genomic rearrangements, in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. Here is the latest research.

Non-coding Variants in Cancer (Keystone)

Mutations, single nucleotide variants and large genomic rearrangements in non-coding regions of the genome can have severe consequences such as disruption of transcription factor binding sites and functions of non-coding RNAs and can impact tumor development and progression. This feed focuses on the latest research on non-coding variants in cancer.

Epigenome Engineering (Keystone)

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of DNA methylation. Discover the latest research here.

Related Papers

Nature Chemical Biology

Creating small transcription activating RNAs

Nature Chemical BiologyFebruary 3, 2015
James ChappellJulius B Lucks
© 2020 Meta ULC. All rights reserved

Achieving large dynamic range control of gene expression with a compact RNA transcription-translation regulator

Nucleic Acids Research

Apr 8, 2017

Alexandra M Westbrook, Julius B Lucks

PMID: 28387839

DOI: 10.1093/nar/gkx215

Abstract

RNA transcriptional regulators are emerging as versatile components for genetic network construction. However, these regulators suffer from incomplete repression in their OFF state, making their dynamic range less than that of their protein counterparts. This incomplete repression cause...read more

Mentioned in this Paper

In Vivo
Ridges-off-the-end Syndrome
Transcriptional Regulation
Primary RNA Transcript
Regulation of Biological Process
Transcription Termination
Transcription, Genetic
Antisense RNA
Protein Biosynthesis
Gene Expression
23
40

Similar Papers Found In These Feeds

Epigenome Engineering

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of dna methylation. Discover the latest research here.

HDR in Genome Engineering

Homology-directed repair (HDR) is a double-strand break repair pathway that can be exploited to modify genomes in many organisms. Researchers are now using the CRISPR-Cas system to control the specificity of HDR genome engineering techniques. Here is the latest research.

Related Papers

Nature Chemical Biology

Creating small transcription activating RNAs

Nature Chemical BiologyFebruary 3, 2015
James ChappellJulius B Lucks
Paper Details
References
  • References37
  • Citations5
1234
  • References37
  • Citations5
1
/papers/achieving-large-dynamic-range-control-of-gene/28387839