Achieving Long-Term Biocompatible Silicone via Covalently Immobilized S-Nitroso- N-acetylpenicillamine (SNAP) That Exhibits 4 Months of Sustained Nitric Oxide Release.

ACS Applied Materials & Interfaces
Sean P HopkinsHitesh Handa

Abstract

Ever since the role of endogenous nitric oxide (NO) in controlling a wide variety of biological functions was discovered approximately three decades back, multiple NO-releasing polymeric materials have been developed. However, most of these materials are typically short lived due to the inefficient incorporation of the NO donor molecules within the polymer matrix. In the present study, S-nitroso- N-acetyl penicillamine (SNAP) is covalently attached to poly(dimethylsiloxane) (PDMS) to create a highly stable nitric oxide (NO) releasing material for biomedical applications. By tethering SNAP to the cross-linker of PDMS, the NO donor is unable to leach into the surrounding environment. This is the first time that a sustainable NO release and bacterial inhibition for over 125 days has been achieved by any NO-releasing polymer with supporting evidence of potential long-term hemocompatibility and biocompatibility. The material proves to have very high antibacterial efficacy against Staphylococcus aureus by demonstrating a 99.99% reduction in the first 3 days in a continuous flow CDC bioreactor, whereas a similar inhibitory potential of 99.50% was maintained by the end of 1 month. Hemocompatibility of SNAP-PDMS was tested using a rabbi...Continue Reading

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Citations

Jul 17, 2020·Frontiers in Bioengineering and Biotechnology·Jingdong RaoXin Zhao
Apr 7, 2020·The Journal of Trauma and Acute Care Surgery·Teryn R RobertsAndriy I Batchinsky
Jan 3, 2021·Pediatric Surgery International·Brian P FallonRonald B Hirschl
Feb 7, 2021·Journal of Colloid and Interface Science·Sama GhaleiHitesh Handa
Oct 26, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yong LiuLinqi Shi
Mar 11, 2021·Biomaterials Science·Manjyot Kaur ChugElizabeth J Brisbois
Apr 9, 2021·Advanced Healthcare Materials·Lars CrawfordBuddy Ratner
Apr 10, 2020·ACS Applied Materials & Interfaces·Ryan DevineHitesh Handa
Aug 27, 2021·ACS Biomaterials Science & Engineering·Meili ZhangJohn F Fraser

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