Achilles tendon enthesitis evaluated by MRI assessments in patients with axial spondyloarthritis and psoriatic arthritis: a report of the methodology of the ACHILLES trial.

BMC Musculoskeletal Disorders
Xenofon BaraliakosFrank Behrens

Abstract

The currently available scoring methods for enthesitis are often measures of pain but not of inflammation at entheseal sites. The Outcome Measures in Rheumatology Clinical Trials (OMERACT) psoriatic arthritis (PsA) magnetic resonance imaging (MRI) scoring system (PsAMRIS) assesses inflammation and damage in PsA and was particularly developed for the hands. The ACHILLES trial used clinical measures for heel enthesitis in combination with MRI scoring based on PsAMRIS. Patients (age ≥ 18 years) with spondyloarthritis (SpA) and PsA were included in the trial if they presented with clinical and MRI-positive heel enthesitis. MRI of the affected heel was performed at three time points: screening, Week 24 and Week 52. Inflammatory MRI findings (tendinitis, bursitis and bone marrow oedema [BME]) in the area of the Achilles tendon and/or plantar aponeurosis, periarticular inflammation of the ankle joint and heel erosion were assessed qualitatively (absent/present). In addition, BME and bone erosion were quantitatively assessed based on PsAMRIS, where their proportion was compared to the volume of the affected bone. Mean scores of BME and bone erosion quantification were calculated, and the mean composite score (based on PsAMRIS) was calc...Continue Reading

References

Oct 17, 2015·Arthritis & Rheumatology·Amy S KehlMichael H Weisman
Nov 22, 2017·Nature Reviews. Rheumatology·Georg SchettDennis McGonagle

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Citations

Apr 15, 2021·European Journal of Radiology Open·Pawel SzaroMichael Carmont
Sep 3, 2021·Therapeutic Advances in Musculoskeletal Disease·Jürgen BraunXenofon Baraliakos

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Methods Mentioned

BETA
imaging techniques

Clinical Trials Mentioned

NCT02771210

Software Mentioned

ACHILLES
PsAMRIS
OMERACT

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