PMID: 8615082Jan 1, 1995Paper

Achromatic neurons in the cortex of progressive supranuclear palsy

Acta Neuropathologica
I R Mackenzie, L P Hudson

Abstract

Achromatic neurons (AN) in the cerebral cortex are a characteristic feature of several neurodegenerative conditions including Pick's disease, corticobasal degeneration and some cases of primary progressive aphasia. Although AN are occasionally seen in some other diseases, their presence in progressive supranuclear palsy (PSP) has not been previously documented. We found significant numbers of AN in the cerebral cortex of five out of seven cases which had been diagnosed pathologically as PSP. The identification of AN was greatly facilitated by the use of neurofilament immunohistochemistry. The entorhinal and transentorhinal cortices were most frequently involved, but in several cases AN were also seen throughout the neocortex. The presence and number of AN roughly correlated with a history of clinical dementia. This suggests that cortical AN may be a common and important pathological finding in PSP.

References

Jan 1, 1992·Acta Neuropathologica·H BraakJ Bohl
Sep 1, 1990·Journal of the Neurological Sciences·C F LippaN Fontneau
Sep 1, 1991·Journal of Neurology·S SasakiC Toyoda
Jun 1, 1991·Neurology·C F LippaD A Drachman
Aug 1, 1990·Neurology·D E RileyS Black
Oct 1, 1989·Brain : a Journal of Neurology·W R GibbC D Marsden
Jan 1, 1986·Annals of Neurology·P J Whitehouse
Jan 1, 1986·Acta Neuropathologica·H MoriH Yamanouchi
May 1, 1986·Journal of Neuropathology and Experimental Neurology·A W ClarkJ T Coyle
Feb 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·M L AlbertA L Willis
Jan 1, 1971·Acta Neuropathologica·K Jellinger
Jan 1, 1968·Archives of Neurology·J J RebeizE P Richardson
Aug 1, 1984·Archives of Neurology·J L Cummings, D F Benson
Nov 1, 1994·Neurology·A KerteszD G Munoz
Jan 1, 1994·Acta Neuropathologica·K WakabayashiS Tokiguchi

❮ Previous
Next ❯

Citations

Jul 2, 2003·Annals of Neurology·David G MunozVictoria Zhukareva
Mar 14, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Richard A Armstrong, Nigel J Cairns
Feb 25, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J Keith-Rokosh, L C Ang
Oct 19, 2006·Parkinsonism & Related Disorders·Richard A ArmstrongNigel J Cairns
Dec 1, 2017·Journal of Neuropathology and Experimental Neurology·Heiko Braak, Kelly Del Tredici
Nov 15, 2002·Journal of Neuropathology and Experimental Neurology·D W DicksonUNKNOWN Office of Rare Diseases of the National Institutes of Health
Dec 1, 1996·Annals of Neurology·C BergeronA E Lang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.