Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy.

Angewandte Chemie
Bingbing SunJan C M van Hest

Abstract

Inspired by the dynamic morphology control of molecular assemblies in biological systems, we have developed pH-responsive transformable peptide-based nanoparticles for photodynamic therapy (PDT) with prolonged tumor retention times. The self-assembled peptide-porphyrin nanoparticles transformed into nanofibers when exposed to the acidic tumor microenvironment, which was mainly driven by enhanced intermolecular hydrogen bond formation between the protonated molecules. The nanoparticle transformation into fibrils improved their singlet oxygen generation ability and enabled high accumulation and long-term retention at tumor sites. Strong fluorescent signals of these nanomaterials were detected in tumor tissue up to 7 days after administration. Moreover, the peptide assemblies exhibited excellent anti-tumor efficacy via PDT in vivo. This in situ fibrillar transformation strategy could be utilized to design effective stimuli-responsive biomaterials for long-term imaging and therapy.

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Citations

Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paolo DogniniFrancesca Giuntini
Apr 22, 2021·Biomedical Materials·Mengjiao ZhouHaijun Yu
Apr 27, 2021·ChemMedChem·Irene ParamioGema de la Torre
May 18, 2021·Bioactive Materials·Xiaohua ZhengHaijun Yu
Jun 20, 2021·Advanced Science·Jiating XuYujie Fu
Jul 14, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jian LiShoufa Han
Jul 29, 2021·Chemical Communications : Chem Comm·Jian ZhangBo Tang
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fanny d'OrlyéAnne Varenne
Sep 4, 2021·Advanced Drug Delivery Reviews·Hayoon JeongKun Na
Nov 3, 2021·Nano Convergence·Jessica A Kemp, Young Jik Kwon

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Methods Mentioned

BETA
amidation
infrared spectroscopy
fluorescence imaging

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