Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer

Nature Reviews. Gastroenterology & Hepatology
José B Sáenz, Jason C Mills

Abstract

Subjected to countless daily injuries, the stomach still functions as a remarkably efficient digestive organ and microbial filter. In this Review, we follow the lead of the earliest gastroenterologists who were fascinated by the antiseptic and digestive powers of gastric secretions. We propose that it is easiest to understand how the stomach responds to injury by stressing the central role of the most important gastric secretion, acid. The stomach follows two basic patterns of adaptation. The superficial response is a pattern whereby the surface epithelial cells migrate and rapidly proliferate to repair erosions induced by acid or other irritants. The stomach can also adapt through a glandular response when the source of acid is lost or compromised (that is, the process of oxyntic atrophy). We primarily review the mechanisms governing the glandular response, which is characterized by a metaplastic change in cellular differentiation known as spasmolytic polypeptide-expressing metaplasia (SPEM). We propose that the stomach, like other organs, exhibits marked cellular plasticity: the glandular response involves reprogramming mature cells to serve as auxiliary stem cells that replace lost cells. Unfortunately, such plasticity might...Continue Reading

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Citations

Aug 24, 2018·Current Opinion in Gastroenterology·David Y Graham, Winnie Y Zou
Apr 11, 2019·The Journal of Physiology·Charles J Cho, Jason C Mills
Jul 11, 2019·Current Gastroenterology Reports·Gian M GaluraRichard McCallum
Feb 23, 2018·The EMBO Journal·Spencer G WilletJason C Mills
Apr 7, 2020·The Journal of Clinical Investigation·Manikandan PalrasuAlexander I Zaika
Apr 7, 2020·The Journal of Clinical Investigation·José B Sáenz, Jason C Mills
Feb 21, 2019·Cellular and Molecular Life Sciences : CMLS·Alexios-Fotios A MentisAthanasios G Papavassiliou
Jul 25, 2018·Disease Models & Mechanisms·Joseph Burclaff, Jason C Mills
Jun 28, 2018·Digestive Diseases and Sciences·Ramon U Jin, Jason C Mills
Sep 2, 2018·Disease Models & Mechanisms·Joseph Burclaff, Jason C Mills
May 10, 2019·Cellular and Molecular Gastroenterology and Hepatology·Anne R MeyerJames R Goldenring
Apr 1, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Massimo RuggePeter Malfertheiner
Jul 3, 2018·Gastroenterology·Jason C Mills, Linda C Samuelson
Jul 5, 2021·Cellular and Molecular Gastroenterology and Hepatology·Jingwen LiuYongliang Zhu
Sep 22, 2021·Cellular and Molecular Gastroenterology and Hepatology·Min-Jiao PangZhen-Ning Wang
Oct 1, 2021·Frontiers in Physiology·Kethleen Mesquita da SilvaPatrícia Gama
Aug 7, 2021·Cellular and Molecular Gastroenterology and Hepatology·Jonathan T BusadaPerry J Blackshear
Oct 26, 2021·Gastroenterology·Zhibo MaKathleen E DelGiorno
Nov 4, 2021·Gastroenterology·James R Goldenring, Jason C Mills

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