Acid-base and electrolyte abnormalities in patients with acute leukemia

American Journal of Hematology
H J MilionisM S Elisaf

Abstract

Disturbances of acid-base balance and electrolyte abnormalities are commonly seen in patients with acute leukemia. Our study aimed at illuminating the probable pathogenetic mechanisms responsible for these disturbances in patients with acute leukemia admitted to our hospital. We studied 66 patients (24 men and 44 women) aged between 17 and 87 years old on their admission and prior to any therapeutic intervention. Patients with diabetes mellitus, acute or chronic renal failure, hepatic failure, patients receiving drugs that influence acid-base status and electrolyte parameters during the last month, such as corticosteroids, cisplatin, diuretics, antacids, aminoglycosides, amphotericin, penicillin, and K(+), PO(4)(3-), or Mg(2+) supplements were excluded. Forty-one patients had at least one acid-base or electrolyte disturbance. There were no significant differences in the incidence of acid-base balance and electrolyte abnormalities between patients with acute myeloid leukemia (AML) and patients with acute lymphoblastic leukemia (ALL). The most frequent electrolyte abnormality was hypokalemia, observed in 41 patients (63%), namely in 34 patients with AML, and 7 with ALL; the main underlying pathophysiologic mechanism was inappropr...Continue Reading

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Citations

May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eleni T BairaktariMoses S Elisaf
Dec 24, 2013·Advances in Chronic Kidney Disease·Mitchell H Rosner, Alan C Dalkin
Dec 24, 2013·Advances in Chronic Kidney Disease·Randy L Luciano, Ursula C Brewster
Jan 22, 2008·European Journal of Internal Medicine·George MiltiadousMoses Elisaf
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Nov 30, 2005·European Journal of Haematology·Theodosios D FilippatosMoses S Elisaf
Dec 15, 2010·Seminars in Nephrology·Norbert LameireRaymond Vanholder
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Jun 14, 2016·Environmental Research·Jerome NriaguBasem Shomar
Jan 7, 2017·Journal of Pediatric Hematology/oncology·Szymon JanczarWojciech Mlynarski
Aug 26, 2006·Nature Clinical Practice. Nephrology·Jamshid Amanzadeh, Robert F Reilly
Aug 27, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jacob Atsmon, Eran Dolev
Mar 2, 2018·Biology Letters·Gustav van NiekerkAnna-Mart Engelbrecht
Jun 10, 2003·Journal of Pediatric Hematology/oncology·Mohammed Hayek, Ashok Srinivasan
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Apr 24, 2018·Biological Trace Element Research·Hasan Imran AfridiFarah Naz Talpur
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Jan 14, 2020·Porto Biomedical Journal·José António Ferraz GonçalvesLuciana Sousa
Jun 9, 2020·Frontiers in Oncology·Ignazio VerziccoAderville Cabassi

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