PMID: 7047862Apr 1, 1982

Acid-base and metabolic responses to anion infusion in the anesthetized dog

Kidney International
R L WathenL C Meyer

Abstract

This study evaluated the acid-base and metabolic effects of several organic anions which might have application in the correction of metabolic acidosis during hemodialysis. Anesthetized dogs were infused intravenously with the sodium salts of either chloride, bicarbonate, acetate, lactate, or pyruvate. Acetate perturbated metabolism more than any of the other organic anions infused. These perturbations included hypoxemia, reductions in serum potassium and phosphorus, a decrease in plasma, glucose, and increases in intermediary metabolites such as lactate, acetoacetate and beta-hydroxybutyrate. Transferance of our findings to hemodialysis suggests that acetate would compromise the ability of dialysis to reduce body burdens of potassium and phosphorus and provide proper base repletion. Pyruvate would appear superior to acetate as a base substitute by virtue of its lesser effects on oxygen consumption and electrolyte distribution and its capacity to produce glucose. However, the significant production of lactate with pyruvate infusion, coupled with diffusive losses of bicarbonate during dialysis and the possible instability of pyruvate in solution, would still hinder proper base repletion. Bicarbonate generation with lactate infus...Continue Reading

References

Nov 1, 1975·Kidney International·S GarellaS I Kahn
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Citations

Dec 1, 1993·Respiration Physiology·S Bharma, William K Milsom
Nov 1, 1982·Artificial Organs·P Keshaviah
Nov 1, 1982·Artificial Organs·R A Ward, R L Wathen
Nov 1, 1982·Artificial Organs·W D DavidsonK Wasserman
Sep 1, 1982·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P Keshaviah, F L Shapiro
Jul 1, 1985·Metabolism: Clinical and Experimental·R A WardL C Thompson
Feb 1, 1988·Alcoholism, Clinical and Experimental Research·A SuokasR Ylikahri
Apr 10, 2016·Hemodialysis International·Jean-Philippe BertocchioPhilippe Rieu
Feb 28, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mikkel T ThomsenMark Bayley
Jan 11, 2008·American Journal of Physiology. Renal Physiology·Ira KurtzMinhtri K Nguyen
Nov 1, 2017·The Journal of Clinical Endocrinology and Metabolism·Thomas Remer
Aug 1, 1989·The American Journal of Physiology·G M FeldmanA Kleinzeller

Related Concepts

Acetic Acids
Anion Gap
Metabolic Acidosis
Abufne
Anesthesia Procedures
Anions
Carbonic Acid Ions
Blood Gas Analysis
Blood Glucose
Diastolic Blood Pressure

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