Jul 1, 1976

Acid-base changes in milk and blood of rats in acidosis and alkalosis

The American Journal of Physiology
R YagilG M Berlyne

Abstract

Lactating white rats (Rattus norvegicus) were subjected to metabolic and respiratory acidosis and metabolic alkalosis. Before and during the various treatments, the acid-base status of heart blood and milk was determined. Acute metabolic acidosis lowered the pH of plasma and milk; Pco(2) and bicarbonate concentrations in plasma were lowered, and in milk Pco(2) was raised and the bicarbonate concentration remained unchanged. Respiratory acidosis and acetazolamide caused a drop in blood pH and in blood and milk bicarbonate concentrations; milk pH remained unchanged, but Pco(2) was raised in both plasma and milk. Acute metabolic alkalosis raised the blood pH and milk Pco(2); plasma Pco(2) and bicarbonate concentrations in blood and milk remained unchanged. The data show that greater changes occur in acid-base parameters of blood than milk when animals are exposed to acidifying and alkalinizing stimuli.

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Mentioned in this Paper

Metabolic Process, Cellular
Acetazolamide
Carbonic Acid Ions
Acidosis, Respiratory
Gases, Blood, pH Only
Lactation, Prolonged
Anion Gap
In Blood
Blood pH
Bicarbonate Measurement

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