PMID: 36322Jan 1, 1979

Acid-base disturbance in patients with fulminant hepatic failure

Gastroenterologia Japonica
Y KosakaH Takezawa


Forty-two arterial blood pH and gas determinations were carried out on 11 patients with fulminant hepatic failure. The most common type of acid-base disturbance was that of respiratory alkalosis in 22 cases (52.4%). This was partially compensated in 13 subjects (31.0%) while an accompanying metabolic alkalosis was present in 9 (21.5%). Partially compensated metabolic acidosis was observed on 15 occasions (35.7%), all of which were in patients with laboratory evidence of impaired renal failure. The mental status of the patients was evaluated in each of the categories of acid-base disturbances. Some degree of correlation was evident between the PCO2 and the magnitude of base excess and that of the severity of the encephalopathy. The lower PCO2 and greater negative base excess values tended to be nearly always present in totally comatose subjects. By contrast, there was no clear cut relationship between pH and mental state.


Jul 29, 2006·The International Journal of Artificial Organs·T NakaP Angus
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Oct 30, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·H C van Anken, M E Schiphorst
Nov 22, 1969·Lancet·I M JamesM Garassini
Mar 1, 1967·Medicine·R MulhausenA Blumentals
Dec 1, 1967·The American Journal of the Medical Sciences·M S Karetzky, J C Mithoefer
Jun 1, 1956·A.M.A. Archives of Internal Medicine·P VANAMEEK E ROBERTS
Nov 1, 1956·Journal of Applied Physiology·J W POPPELLP VANAMEE
Jul 1, 1959·The American Journal of Medicine·M P TYOR, H O SIEKER
Jan 1, 1960·Scandinavian Journal of Clinical and Laboratory Investigation·O S ANDERSEN, K ENGEL
Jan 1, 1963·Scandinavian Journal of Clinical and Laboratory Investigation·V REINICKES MULLERTZ
Feb 1, 1960·The American Journal of Medicine·H O HEINEMANNJ P MIJNSSEN
Aug 1, 1960·The Journal of Clinical Investigation·J B POSNER, F PLUM

Related Concepts

Arterial Blood pH Measurement
Base Excess Measurement
Kidney Failure
Compensated Metabolic Acidosis
Renal Insufficiency
Liver Failure, Acute
Brain Damage, Chronic
Fulminant Hepatic Failure With Cerebral Edema

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